Synthesis of 6- and 7-(1,2,3-trihydroxy-1,2-O-isopropyl-denepropyl)pteridines and deoxygenation of their 3′-hydroxy groups

Tadashi Hanaya, Daisuke Takayama, Hiroshi Yamamoto

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Treatment of 3,4-O-isopropylidene-L-threo-pentos-2-ulose (7) with 5,6-diamino-1,3-dimethyluracil (8) afforded 1,3-dimethyl-6-[(1R,2S)-1,2,3-trihydroxy-1,2-O-isopropylidenepropyl]lumazine (9a) and its 7-substituted isomer (9b). Deoxygenation of 3′-hydroxy groups of 9a,b was investigated in connection with a practical transformation of neopterin into biopterin.

Original languageEnglish
Pages (from-to)355-365
Number of pages11
JournalHeterocycles
Volume70
DOIs
Publication statusPublished - Dec 31 2006

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of 6- and 7-(1,2,3-trihydroxy-1,2-O-isopropyl-denepropyl)pteridines and deoxygenation of their 3′-hydroxy groups'. Together they form a unique fingerprint.

  • Cite this