Synthesis of 3,3-disubstituted oxindoles by palladium-catalyzed tandem reaction of 2-(alkynyl)aryl isocyanates with benzylic alcohols

Takeharu Toyoshima, Yusuke Mikano, Tomoya Miura, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A palladium complex sequentially promoted two mechanistically distinct reactions, the first, cyclization of 2-(alkynyl)aryl isocyanates with benzylic alcohols, and the second, [1,3] rearrangement of a benzyl group from oxygen to carbon, furnishing 3,3-disubstituted oxindoles in one pot.

Original languageEnglish
Pages (from-to)4584-4587
Number of pages4
JournalOrganic Letters
Volume12
Issue number20
DOIs
Publication statusPublished - Oct 15 2010
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Synthesis of 3,3-disubstituted oxindoles by palladium-catalyzed tandem reaction of 2-(alkynyl)aryl isocyanates with benzylic alcohols'. Together they form a unique fingerprint.

Cite this