TY - JOUR
T1 - Synthesis of 3-chloro-Δ3-cephem-4-carboxylate by addition/cyclization of allenecarboxylate. Copper(II)-promoted aerobic oxidation of arenesulfinic acids
AU - Tanaka, Hideo
AU - Kikuchi, Ryo
AU - Torii, Sigeru
PY - 1996/5
Y1 - 1996/5
N2 - The selective transformation of allenecarboxylate derived from penicillin into 3-chloro-Δ3-cephem-4-carboxylate was successfully achieved by an addition/cyclization reaction with chloride salts in aerobic media containing a copper(II) catalyst, in which copper(II)-catalyzed aerobic oxidation of in situ generated benzenesulfinate ion into less nucleophilic sulfonate ion prior to the nucleophilic addition of the former ion to the allenecarboxylate would completely eliminate the formation of undesired 3-phenylsulfonyl-Δ3-cephem-4-carboxylate. Under similar aerobic conditions, arenesulfinates salts and arenesulfinic acids were smoothly oxidized to the corresponding sulfonate salts and sulfonic acids, respectively.
AB - The selective transformation of allenecarboxylate derived from penicillin into 3-chloro-Δ3-cephem-4-carboxylate was successfully achieved by an addition/cyclization reaction with chloride salts in aerobic media containing a copper(II) catalyst, in which copper(II)-catalyzed aerobic oxidation of in situ generated benzenesulfinate ion into less nucleophilic sulfonate ion prior to the nucleophilic addition of the former ion to the allenecarboxylate would completely eliminate the formation of undesired 3-phenylsulfonyl-Δ3-cephem-4-carboxylate. Under similar aerobic conditions, arenesulfinates salts and arenesulfinic acids were smoothly oxidized to the corresponding sulfonate salts and sulfonic acids, respectively.
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U2 - 10.1246/bcsj.69.1391
DO - 10.1246/bcsj.69.1391
M3 - Article
AN - SCOPUS:0029944259
VL - 69
SP - 1391
EP - 1396
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
SN - 0009-2673
IS - 5
ER -