Synthesis of 3-alkenyl-Δ3-cephems via sequential reductive 1,2- elimination/ addition/cyclization in an alkenyltin/copper(I) chloride/bpy system

Hideo Tanaka, Yoshihisa Tokumaru, Sigeru Torii

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A sequential reductive 1,2-elimination-addition-cyclization of 3,4- disubstituted butenoates derived from penicillin is performed successfully by treatment with alkenyltin, copper(I) chloride and 2,2'-bipyridine (bpy) in N- methyl-2-pyrrolidinone (NMP) to afford 3-alkenyl-Δ3-cephems.

Original languageEnglish
Pages (from-to)774-776
Number of pages3
JournalSynlett
Issue number6
DOIs
Publication statusPublished - Jan 1 1999

Keywords

  • 3,4-disubstituted butenoate
  • 3-alkeyl-Δ-cephems
  • Addition/cyclization
  • Alkenyltin/CuCl system
  • Reductive 1,2- elimination

ASJC Scopus subject areas

  • Organic Chemistry

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