Synthesis of 3-alkenyl-Δ3-cephems via sequential reductive 1,2- elimination/ addition/cyclization in an alkenyltin/copper(I) chloride/bpy system

Hideo Tanaka; Yoshihisa Tokumaru; Sigeru Torii

doi:10.1055/s-1999-2735

Synthesis of 3-alkenyl-Δ³-cephems via sequential reductive 1,2- elimination/ addition/cyclization in an alkenyltin/copper(I) chloride/bpy system

Hideo Tanaka, Yoshihisa Tokumaru, Sigeru Torii

Faculty of Engineering

Research output: Contribution to journal › Article

5 Citations (Scopus)

Abstract

A sequential reductive 1,2-elimination-addition-cyclization of 3,4- disubstituted butenoates derived from penicillin is performed successfully by treatment with alkenyltin, copper(I) chloride and 2,2'-bipyridine (bpy) in N- methyl-2-pyrrolidinone (NMP) to afford 3-alkenyl-Δ³-cephems.

Original language	English
Pages (from-to)	774-776
Number of pages	3
Journal	Synlett
Issue number	6
DOIs	https://doi.org/10.1055/s-1999-2735
Publication status	Published - Jan 1 1999

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Keywords

3,4-disubstituted butenoate
3-alkeyl-Δ-cephems
Addition/cyclization
Alkenyltin/CuCl system
Reductive 1,2- elimination

ASJC Scopus subject areas

Organic Chemistry

Cite this

Tanaka, H., Tokumaru, Y., & Torii, S. (1999). Synthesis of 3-alkenyl-Δ³-cephems via sequential reductive 1,2- elimination/ addition/cyclization in an alkenyltin/copper(I) chloride/bpy system. Synlett, (6), 774-776. https://doi.org/10.1055/s-1999-2735

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10.1055/s-1999-2735