Synthesis of 2-Substituted Propenes by Bidentate Phosphine-Assisted Methylenation of Acyl Fluorides and Acyl Chlorides with AlMe 3

Xiu Wang, Zhenhua Wang, Yuya Asanuma, Yasushi Nishihara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Bidentate phosphine-assisted methylenation of acyl fluorides and acyl chlorides with substituted with aryl, alkenyl, and alkyl groups trimethylaluminum afforded an array of 2-substituted propene derivatives. The addition of a catalytic amount of DPPM increased an efficiency of the reactions. Trimethylaluminum as the methylenation reagent not only eliminates the presynthesis of methylene transfer reagent, but provides an efficient method for the synthesis of a series of 2-substituted propenes.

Original languageEnglish
Pages (from-to)3640-3643
Number of pages4
JournalOrganic Letters
Volume21
Issue number10
DOIs
Publication statusPublished - May 17 2019

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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