Synthesis of (1H)-isochromen-1-imines by nickel-catalyzed reaction of 2-iodobenzamides with alkynes

Tomoya Miura; Kentaro Hiraga; Takeharu Toyoshima; Motoshi Yamauchi; Masahiro Murakami

doi:10.1246/cl.2012.798

Synthesis of (1H)-isochromen-1-imines by nickel-catalyzed reaction of 2-iodobenzamides with alkynes

Tomoya Miura, Kentaro Hiraga, Takeharu Toyoshima, Motoshi Yamauchi, Masahiro Murakami

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

2-Iodobenzamides reacted with alkynes in the presence of a nickel(0)/P(4-ClC ₆H ₄) ₃ catalyst to produce substituted (1H)-isochromen-1-imines. The reaction proceeded through the formation of an oxanickelacycle, alkyne insertion, and reductive elimination.

Original language	English
Pages (from-to)	798-800
Number of pages	3
Journal	Chemistry Letters
Volume	41
Issue number	8
DOIs	https://doi.org/10.1246/cl.2012.798
Publication status	Published - 2012
Externally published	Yes

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2012.798

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title = "Synthesis of (1H)-isochromen-1-imines by nickel-catalyzed reaction of 2-iodobenzamides with alkynes",

abstract = "2-Iodobenzamides reacted with alkynes in the presence of a nickel(0)/P(4-ClC 6H 4) 3 catalyst to produce substituted (1H)-isochromen-1-imines. The reaction proceeded through the formation of an oxanickelacycle, alkyne insertion, and reductive elimination.",

author = "Tomoya Miura and Kentaro Hiraga and Takeharu Toyoshima and Motoshi Yamauchi and Masahiro Murakami",

year = "2012",

doi = "10.1246/cl.2012.798",

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publisher = "Chemical Society of Japan",

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T1 - Synthesis of (1H)-isochromen-1-imines by nickel-catalyzed reaction of 2-iodobenzamides with alkynes

AU - Miura, Tomoya

AU - Hiraga, Kentaro

AU - Toyoshima, Takeharu

AU - Yamauchi, Motoshi

AU - Murakami, Masahiro

PY - 2012

Y1 - 2012

N2 - 2-Iodobenzamides reacted with alkynes in the presence of a nickel(0)/P(4-ClC 6H 4) 3 catalyst to produce substituted (1H)-isochromen-1-imines. The reaction proceeded through the formation of an oxanickelacycle, alkyne insertion, and reductive elimination.

AB - 2-Iodobenzamides reacted with alkynes in the presence of a nickel(0)/P(4-ClC 6H 4) 3 catalyst to produce substituted (1H)-isochromen-1-imines. The reaction proceeded through the formation of an oxanickelacycle, alkyne insertion, and reductive elimination.

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JF - Chemistry Letters

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ER -

Synthesis of (1H)-isochromen-1-imines by nickel-catalyzed reaction of 2-iodobenzamides with alkynes

Abstract

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