Synthesis of 1(2H)-isoquinolones by the nickel-catalyzed denitrogenative alkyne insertion of 1,2,3-benzotriazin-4(3H)-ones

Tomoya Miura, Motoshi Yamauchi, Masahiro Murakami

Research output: Contribution to journalArticlepeer-review

119 Citations (Scopus)

Abstract

(Chemical Equation Presented) 1,2,3-Benzotriazin-4(3H)-ones reacted with internal and terminal alkynes in the presence of a nickel(0)/phosphine catalyst to give a wide range of substituted 1(2H)-isoquinolones in high yield. The reaction proceeded through denitrogenative activation of the triazinone moiety and the following insertion of alkynes.

Original languageEnglish
Pages (from-to)3085-3088
Number of pages4
JournalOrganic Letters
Volume10
Issue number14
DOIs
Publication statusPublished - 2008
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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