Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes

Kaoru Tsuchiya; Yoshiaki Hamada; Araki Masuyama; Masatomo Nojima; Kevin J. McCullough; Hye Sook Kim; Yasuharu Shibata; Yusuke Wataya

doi:10.1016/S0040-4039(99)00653-X

Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes

Kaoru Tsuchiya, Yoshiaki Hamada, Araki Masuyama, Masatomo Nojima, Kevin J. McCullough, Hye Sook Kim, Yasuharu Shibata, Yusuke Wataya

Research output: Contribution to journal › Article

53 Citations (Scopus)

Abstract

(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3-6) in the presence of CsOH-H₂O in DMF affording the corresponding spiro- 1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum.

Original language	English
Pages (from-to)	4077-4080
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	21
DOIs	https://doi.org/10.1016/S0040-4039(99)00653-X
Publication status	Published - May 21 1999

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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Tsuchiya, K., Hamada, Y., Masuyama, A., Nojima, M., McCullough, K. J., Kim, H. S., Shibata, Y., & Wataya, Y. (1999). Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes. Tetrahedron Letters, 40(21), 4077-4080. https://doi.org/10.1016/S0040-4039(99)00653-X

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abstract = "(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3-6) in the presence of CsOH-H2O in DMF affording the corresponding spiro- 1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum.",

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AU - Tsuchiya, Kaoru

AU - Hamada, Yoshiaki

AU - Masuyama, Araki

AU - Nojima, Masatomo

AU - McCullough, Kevin J.

AU - Kim, Hye Sook

AU - Shibata, Yasuharu

AU - Wataya, Yusuke

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Y1 - 1999/5/21

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