@article{18458b09a36e4ba39ce80aab5f6a46f8,
title = "Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes",
abstract = "(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3-6) in the presence of CsOH-H2O in DMF affording the corresponding spiro- 1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum.",
author = "Kaoru Tsuchiya and Yoshiaki Hamada and Araki Masuyama and Masatomo Nojima and McCullough, {Kevin J.} and Kim, {Hye Sook} and Yasuharu Shibata and Yusuke Wataya",
note = "Funding Information: Acknowledgements. This work was supported in part by a Grant-in-Aid for Scientific Research on Priority Areas (10153238 and 10166211) from the Ministry of Education, Science, Culture and Sports of Japan. We also thank the British Council (Tokyo) for the award of travel grant to A.M., M.N. and K.JM. Copyright: Copyright 2007 Elsevier B.V., All rights reserved.",
year = "1999",
month = may,
day = "21",
doi = "10.1016/S0040-4039(99)00653-X",
language = "English",
volume = "40",
pages = "4077--4080",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Limited",
number = "21",
}