Synthesis, crystal structure and anti-malarial activity of novel spiro- 1,2,4,5-tetraoxacycloalkanes

Kaoru Tsuchiya, Yoshiaki Hamada, Araki Masuyama, Masatomo Nojima, Kevin J. McCullough, Hye Sook Kim, Yasuharu Shibata, Yusuke Wataya

Research output: Contribution to journalArticlepeer-review

56 Citations (Scopus)

Abstract

(Cycloalkylidene)bishydroperoxides 3 react with 1,n-dihaloalkanes (n = 3-6) in the presence of CsOH-H2O in DMF affording the corresponding spiro- 1,2,4,5-tetraoxacycloalkanes 4 in moderate yields. Compound 4ba exhibits significant antimalarial activity in vitro against P. falciparum.

Original languageEnglish
Pages (from-to)4077-4080
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number21
DOIs
Publication statusPublished - May 21 1999

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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