Synthesis, characterization of some new 1-aroyl-3-(4-aminosulfonylphenyl) thioureas and crystal structure of 1-(3,4,5-trimethoxybenzoyl)- 3-(4-aminosulfonylphenyl)thiourea

Aamer Saeed, Amara Mumtaz, Hiroyuki Ishida

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Abstract

A small library of novel 1-aroyl-3-(4-aminosulfonylphenyl)thiourea derivatives was synthesized by the reaction of sulfanilamide with substituted aroyl isothiocyanates in dry acetonitrile. The scope of the reaction was indicated by the synthesis of 1-undecanoyl-3-(4-aminosulfonylphenyl)thiourea, an acyl derivative involving alkanoyl isothiocyanate. All the compounds have been characterized by analytical and spectroscopic methods and in one case by single-crystal X-ray diffraction data.

Original languageEnglish
Pages (from-to)45-54
Number of pages10
JournalJournal of Sulfur Chemistry
Volume32
Issue number1
DOIs
Publication statusPublished - Feb 2011

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Keywords

  • 1-aroyl-3-(4-aminosulfonylphenyl)thioureas
  • aryl/acyl isothiocyanates
  • sulfonamides

ASJC Scopus subject areas

  • Chemistry(all)

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