Synthesis and transport characterization of alginate/aminopropyl-silicate/alginate microcapsule: Application to bioartificial pancreas

Shinji Sakai, Tsutomu Ono, Hiroyuki Ijima, Koei Kawakami

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

To develop a novel type of immunoisolation membrane for a microcapsule-shaped bioartificial pancreas, we attempted to use a sol-gel synthesized silicate. An aminopropyl-silicate membrane derived from 3-aminopropyltrimethoxysilane and tetramethoxysilane was formed on Ca-alginate gel beads via electrostatic interaction. The positively charged amino groups remaining on the surface of the resultant gel beads were neutralized by immersion in an aqueous Na-alginate solution. From measurements of the partition coefficients and effective diffusivities of different substances to the gel beads, it was found that the aminopropyl-silicate membrane prepared under optimized composition of silicon alkoxide precursors successfully rejected γ-globulin, giving good permeability to substances having a low molecular weight. Islets could be encapsulated within the newly developed microcapsules while retaining their ability to secrete insulin.

Original languageEnglish
Pages (from-to)2827-2834
Number of pages8
JournalBiomaterials
Volume22
Issue number21
DOIs
Publication statusPublished - Aug 22 2001
Externally publishedYes

Keywords

  • Alginate
  • Aminopropyl-silicate
  • Bioartificial pancreas
  • Microcapsule
  • Sol-gel method

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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