Synthesis and properties of peptide dendrimers containing fluorescent and branched amino acids

Mizuki Kitamatsu, Mayumi Kitabatake, Yoshiteru Noutoshi, Takashi Ohtsuki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this report, we describe dendritic peptides possessing central fluorescent amino acids with adjacent branched amino acids. These fluorescent-peptide dendrimers were prepared using (9-fluorenyl)methoxycarbonyl (Fmoc)-based solid-phase peptide synthesis and Fmoc-derivative fluorescent and branched amino acids. The branched amino acids featured multiple carboxylic acids in their side chains, making the fluorescent-peptide dendrimers highly water-soluble compared with the analogous peptides containing the fluorescent amino acids only. The branched amino acid units also improved the fluorescence intensity of the dendrimers. Based on high-pressure liquid chromatography and fluorescence spectroscopy results, we determined that the fluorescent groups were located in the core and that the carboxylic acids were located on the surface of the dendrimers. Fluorescence resonance energy transfer was achieved among the three proximal fluorescent groups in one of the fabricated fluorescent-peptide dendrimers.

Original languageEnglish
Pages (from-to)64-70
Number of pages7
JournalBiopolymers
Volume100
Issue number1
DOIs
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Medicine(all)

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