Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes

Yoshiaki Hamada, Hidekazu Tokuhara, Araki Masuyama, Masatomo Nojima, Hye-Sook Kim, Kanako Ono, Naoki Ogura, Yusuke Wataya

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).

Original languageEnglish
Pages (from-to)1374-1378
Number of pages5
JournalJournal of Medicinal Chemistry
Volume45
Issue number6
DOIs
Publication statusPublished - Mar 14 2002

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Alkanes
Peroxides
Antimalarials
artemisinine

ASJC Scopus subject areas

  • Organic Chemistry

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Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes. / Hamada, Yoshiaki; Tokuhara, Hidekazu; Masuyama, Araki; Nojima, Masatomo; Kim, Hye-Sook; Ono, Kanako; Ogura, Naoki; Wataya, Yusuke.

In: Journal of Medicinal Chemistry, Vol. 45, No. 6, 14.03.2002, p. 1374-1378.

Research output: Contribution to journalArticle

Hamada, Yoshiaki ; Tokuhara, Hidekazu ; Masuyama, Araki ; Nojima, Masatomo ; Kim, Hye-Sook ; Ono, Kanako ; Ogura, Naoki ; Wataya, Yusuke. / Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes. In: Journal of Medicinal Chemistry. 2002 ; Vol. 45, No. 6. pp. 1374-1378.
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AU - Ogura, Naoki

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