Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes

Yoshiaki Hamada; Hidekazu Tokuhara; Araki Masuyama; Masatomo Nojima; Hye Sook Kim; Kanako Ono; Naoki Ogura; Yusuke Wataya

doi:10.1021/jm010473w

Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes

Yoshiaki Hamada, Hidekazu Tokuhara, Araki Masuyama, Masatomo Nojima, Hye Sook Kim, Kanako Ono, Naoki Ogura, Yusuke Wataya

Research output: Contribution to journal › Article › peer-review

75 Citations (Scopus)

Abstract

Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).

Original language	English
Pages (from-to)	1374-1378
Number of pages	5
Journal	Journal of medicinal chemistry
Volume	45
Issue number	6
DOIs	https://doi.org/10.1021/jm010473w
Publication status	Published - Mar 14 2002

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery

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10.1021/jm010473w

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title = "Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes",

abstract = "Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).",

author = "Yoshiaki Hamada and Hidekazu Tokuhara and Araki Masuyama and Masatomo Nojima and Kim, {Hye Sook} and Kanako Ono and Naoki Ogura and Yusuke Wataya",

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language = "English",

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T1 - Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes

AU - Hamada, Yoshiaki

AU - Tokuhara, Hidekazu

AU - Masuyama, Araki

AU - Nojima, Masatomo

AU - Kim, Hye Sook

AU - Ono, Kanako

AU - Ogura, Naoki

AU - Wataya, Yusuke

PY - 2002/3/14

Y1 - 2002/3/14

N2 - Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).

AB - Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).

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U2 - 10.1021/jm010473w

DO - 10.1021/jm010473w

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JF - Journal of Medicinal Chemistry

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ER -

Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes

Abstract

ASJC Scopus subject areas

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