Synthesis and notable antimalarial activity of acyclic peroxides, 1-(alkyldioxy)-1-(methyldioxy)cyclododecanes

Yoshiaki Hamada, Hidekazu Tokuhara, Araki Masuyama, Masatomo Nojima, Hye-Sook Kim, Kanako Ono, Naoki Ogura, Yusuke Wataya

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Abstract

Of several bis(alkyldioxy)alkanes and the related acyclic peroxides prepared in this study, 1,1-bis(methyldioxy)cyclododecane showed the most notable antimalarial activity particularly in vivo (almost a half of that of artemisinin).

Original languageEnglish
Pages (from-to)1374-1378
Number of pages5
JournalJournal of Medicinal Chemistry
Volume45
Issue number6
DOIs
Publication statusPublished - Mar 14 2002

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ASJC Scopus subject areas

  • Organic Chemistry

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