Synthesis and Neuraminidase Inhibitory Activity of Sialic Acid Analogues with Fluoro, Phosphono, and Sulfo Functionalities

Christopher J. Vavricka, Nongluk Sriwilaijaroen, Yasuo Suzuki, Hiromasa Kiyota

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Methods to synthesize influenza virus inhibitors with fluoro, phosphono, and/or sulfo functional groups are described. The resulting sialic acid analogues are produced from the natural substrate N-acetylneuraminic acid as starting material. Fluorescent assay methods for inhibition of influenza neuraminidase and virus proliferation are also provided.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages303-320
Number of pages18
DOIs
Publication statusPublished - 2022

Publication series

NameMethods in Molecular Biology
Volume2556
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Fluoro-sialic acids
  • Influenza virus
  • Neuraminidase
  • Phosphono-sialic acids
  • Sulfo-sialic acids

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

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