Abstract
Organically modified silicates containing calcium ion have a potential to bond to bone via an apatite layer deposited on their surfaces in the body environment. In this study, we examined the relationship between apatite deposition and the microstructure of the organically modified silicates synthesized from tetraethoxysilane (TEOS) and poly (dimethylsiloxane) (PDMS) with a different amount of calcium nitrate tetrahydrate (Ca(NO3)2·4H2O) hydrochloric acid (HCl). Apatite deposition was evaluated in vitro using a simulated body fluid (Kokubo solution). Copolymerization was confirmed between TEOS and PDMS even if PDMS free from-SiOH termination are used as one of the starting materials. The porosity and Ca content incorporated in the structure depended on the amount of HCl, whereas analysis of 29Si MAS NMR spectra indicates that it caused few effects on the local structure around Si atoms. Apatite-forming ability is enhanced by optimal amounts of HCl and Ca (NO3)2·4H2O. The difference apatite-forming ability among the hybrid gels was attributed to both Ca(II) contents in the structure and aggregation states of the Si-OH groups. Better bioactivity of the hybrid gels is achieved by the release of Ca(II) ions trapped in structure at gelation and the formation of hydrated silica rich in Si-OH.
| Original language | English |
|---|---|
| Pages (from-to) | 89-96 |
| Number of pages | 8 |
| Journal | Journal of Sol-Gel Science and Technology |
| Volume | 21 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Jun 2001 |
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Keywords
- Si MAS NMR
- Bioactivity
- Organically modified silicates
- Sol-gel method
ASJC Scopus subject areas
- Ceramics and Composites
Cite this
Synthesis and in vitro behavior of organically modified silicate containing Ca ions. / Tsuru, Kanji; Aburatani, Yasushi; Yabuta, Takeshi; Hayakawa, Satoshi; Ohtsuki, Chikara; Osaka, Akiyoshi.
In: Journal of Sol-Gel Science and Technology, Vol. 21, No. 1-2, 06.2001, p. 89-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and in vitro behavior of organically modified silicate containing Ca ions
AU - Tsuru, Kanji
AU - Aburatani, Yasushi
AU - Yabuta, Takeshi
AU - Hayakawa, Satoshi
AU - Ohtsuki, Chikara
AU - Osaka, Akiyoshi
PY - 2001/6
Y1 - 2001/6
N2 - Organically modified silicates containing calcium ion have a potential to bond to bone via an apatite layer deposited on their surfaces in the body environment. In this study, we examined the relationship between apatite deposition and the microstructure of the organically modified silicates synthesized from tetraethoxysilane (TEOS) and poly (dimethylsiloxane) (PDMS) with a different amount of calcium nitrate tetrahydrate (Ca(NO3)2·4H2O) hydrochloric acid (HCl). Apatite deposition was evaluated in vitro using a simulated body fluid (Kokubo solution). Copolymerization was confirmed between TEOS and PDMS even if PDMS free from-SiOH termination are used as one of the starting materials. The porosity and Ca content incorporated in the structure depended on the amount of HCl, whereas analysis of 29Si MAS NMR spectra indicates that it caused few effects on the local structure around Si atoms. Apatite-forming ability is enhanced by optimal amounts of HCl and Ca (NO3)2·4H2O. The difference apatite-forming ability among the hybrid gels was attributed to both Ca(II) contents in the structure and aggregation states of the Si-OH groups. Better bioactivity of the hybrid gels is achieved by the release of Ca(II) ions trapped in structure at gelation and the formation of hydrated silica rich in Si-OH.
AB - Organically modified silicates containing calcium ion have a potential to bond to bone via an apatite layer deposited on their surfaces in the body environment. In this study, we examined the relationship between apatite deposition and the microstructure of the organically modified silicates synthesized from tetraethoxysilane (TEOS) and poly (dimethylsiloxane) (PDMS) with a different amount of calcium nitrate tetrahydrate (Ca(NO3)2·4H2O) hydrochloric acid (HCl). Apatite deposition was evaluated in vitro using a simulated body fluid (Kokubo solution). Copolymerization was confirmed between TEOS and PDMS even if PDMS free from-SiOH termination are used as one of the starting materials. The porosity and Ca content incorporated in the structure depended on the amount of HCl, whereas analysis of 29Si MAS NMR spectra indicates that it caused few effects on the local structure around Si atoms. Apatite-forming ability is enhanced by optimal amounts of HCl and Ca (NO3)2·4H2O. The difference apatite-forming ability among the hybrid gels was attributed to both Ca(II) contents in the structure and aggregation states of the Si-OH groups. Better bioactivity of the hybrid gels is achieved by the release of Ca(II) ions trapped in structure at gelation and the formation of hydrated silica rich in Si-OH.
KW - Si MAS NMR
KW - Bioactivity
KW - Organically modified silicates
KW - Sol-gel method
UR - http://www.scopus.com/inward/record.url?scp=0035368385&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035368385&partnerID=8YFLogxK
U2 - 10.1023/A:1011217818285
DO - 10.1023/A:1011217818285
M3 - Article
AN - SCOPUS:0035368385
VL - 21
SP - 89
EP - 96
JO - Journal of Sol-Gel Science and Technology
JF - Journal of Sol-Gel Science and Technology
SN - 0928-0707
IS - 1-2
ER -