Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Masanori Shigeyasu, Masayasu Kuwahara, Masahiko Sisido, Teruhiko Ishikawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.

Original languageEnglish
Pages (from-to)634-635
Number of pages2
JournalChemistry Letters
Issue number7
DOIs
Publication statusPublished - Jan 1 2001

ASJC Scopus subject areas

  • Chemistry(all)

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