Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Masanori Shigeyasu, Masayasu Kuwahara, Masahiko Sisido, Teruhiko Ishikawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.

Original languageEnglish
Pages (from-to)634-635
Number of pages2
JournalChemistry Letters
Issue number7
Publication statusPublished - 2001

Fingerprint

Peptide Nucleic Acids
DNA
Adenine
Melting
Complementary DNA
prolinol

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit. / Shigeyasu, Masanori; Kuwahara, Masayasu; Sisido, Masahiko; Ishikawa, Teruhiko.

In: Chemistry Letters, No. 7, 2001, p. 634-635.

Research output: Contribution to journalArticle

@article{4e8b314ae0184208b5d5b678ec8ccfac,
title = "Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit",
abstract = "A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.",
author = "Masanori Shigeyasu and Masayasu Kuwahara and Masahiko Sisido and Teruhiko Ishikawa",
year = "2001",
language = "English",
pages = "634--635",
journal = "Chemistry Letters",
issn = "0366-7022",
publisher = "Chemical Society of Japan",
number = "7",

}

TY - JOUR

T1 - Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

AU - Shigeyasu, Masanori

AU - Kuwahara, Masayasu

AU - Sisido, Masahiko

AU - Ishikawa, Teruhiko

PY - 2001

Y1 - 2001

N2 - A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.

AB - A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.

UR - http://www.scopus.com/inward/record.url?scp=0035634151&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035634151&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0035634151

SP - 634

EP - 635

JO - Chemistry Letters

JF - Chemistry Letters

SN - 0366-7022

IS - 7

ER -