Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Masanori Shigeyasu; Masayasu Kuwahara; Masahiko Sisido; Teruhiko Ishikawa

doi:10.1246/cl.2001.634

Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Masanori Shigeyasu, Masayasu Kuwahara, Masahiko Sisido, Teruhiko Ishikawa

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A₉)] hybridized with the complementary DNA (T₉). The hybrid showed a very sharp melting curve with T_m = 34 °C.

Original language	English
Pages (from-to)	634-635
Number of pages	2
Journal	Chemistry Letters
Issue number	7
DOIs	https://doi.org/10.1246/cl.2001.634
Publication status	Published - Jan 1 2001

ASJC Scopus subject areas

Chemistry(all)

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10.1246/cl.2001.634

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title = "Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit",

abstract = "A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.",

author = "Masanori Shigeyasu and Masayasu Kuwahara and Masahiko Sisido and Teruhiko Ishikawa",

year = "2001",

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AU - Shigeyasu, Masanori

AU - Kuwahara, Masayasu

AU - Sisido, Masahiko

AU - Ishikawa, Teruhiko

PY - 2001/1/1

Y1 - 2001/1/1

N2 - A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.

AB - A novel oxy-peptide nucleic acid that contains a cis-4-adeninyl-L-prolinol unit in the main chain (PPNA) was synthesized. The peptide nucleic acid with nine adenine units [PPNA(A9)] hybridized with the complementary DNA (T9). The hybrid showed a very sharp melting curve with Tm = 34 °C.

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Synthesis and DNA binding property of a novel peptide nucleic acid that contains cis-4-adeninyl-L-prolinol unit

Abstract

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