Synthesis and chemiluminescent activity of pyridazino[4,5-b]indole-1,4(2H,3H)-diones

Masateru Kurumi, Kenji Sasaki, Hiroko Takata, Taiji Nakayama

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Substituted and non-substituted anilines were transformed to the corresponding triazole derivatives, which were converted to dimethyl indole-2,3-dicarboxylates by photocyclization. The reaction of diester with hydrazine hydrate gave 1,2,3,4-tetrahydro-5H-pyridazino[4,5-b]indole-1,4(2H,3H)-diones (5). Some of compounds (5) were found to have chemiluminescent activity in a similarly to luminol in the presence of hydrogen peroxide and peroxidase in a basic solution.

Original languageEnglish
Pages (from-to)2809-2819
Number of pages11
JournalHeterocycles
Volume53
Issue number12
Publication statusPublished - Dec 1 2000

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

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