TY - JOUR
T1 - Synthesis and characterization of the selenium analog of glutathione disulfide
AU - Tamura, Takashi
AU - Oikawa, Tadao
AU - Ohtaka, Akira
AU - Fujii, Nobutaka
AU - Esaki, Nobuyoshi
AU - Soda, Kenji
PY - 1993/1
Y1 - 1993/1
N2 - We synthesized the selenium analog of glutathione disulfide by a liquid phase method and named it glutaselenone (i.e., γ-L-glutamyl-L-selenocysteinylglycine) diselenide. The selenol of selenocysteine was protected by the p-methoxybenzyl group, which was removed by acidolysis with trifluoroacetic acid in the presence of thioanisol. The overall yield of the final product, glutaselenone diselenide, was about 9% based on the starting compound, Se-(p-methoxybenzyl)-L-selenocysteine. Glutaselenone diselenide showed a broad absorption band between 270 and 400 nm and circular dichroism bands around 270 nm (positive) and 330 nm (negative), which were attributable to diselenide bond.
AB - We synthesized the selenium analog of glutathione disulfide by a liquid phase method and named it glutaselenone (i.e., γ-L-glutamyl-L-selenocysteinylglycine) diselenide. The selenol of selenocysteine was protected by the p-methoxybenzyl group, which was removed by acidolysis with trifluoroacetic acid in the presence of thioanisol. The overall yield of the final product, glutaselenone diselenide, was about 9% based on the starting compound, Se-(p-methoxybenzyl)-L-selenocysteine. Glutaselenone diselenide showed a broad absorption band between 270 and 400 nm and circular dichroism bands around 270 nm (positive) and 330 nm (negative), which were attributable to diselenide bond.
UR - http://www.scopus.com/inward/record.url?scp=0027450708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027450708&partnerID=8YFLogxK
U2 - 10.1006/abio.1993.1021
DO - 10.1006/abio.1993.1021
M3 - Article
C2 - 8434784
AN - SCOPUS:0027450708
VL - 208
SP - 151
EP - 154
JO - Analytical Biochemistry
JF - Analytical Biochemistry
SN - 0003-2697
IS - 1
ER -