Synthesis and characterization of the selenium analog of glutathione disulfide

Takashi Tamura, Tadao Oikawa, Akira Ohtaka, Nobutaka Fujii, Nobuyoshi Esaki, Kenji Soda

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We synthesized the selenium analog of glutathione disulfide by a liquid phase method and named it glutaselenone (i.e., γ-L-glutamyl-L-selenocysteinylglycine) diselenide. The selenol of selenocysteine was protected by the p-methoxybenzyl group, which was removed by acidolysis with trifluoroacetic acid in the presence of thioanisol. The overall yield of the final product, glutaselenone diselenide, was about 9% based on the starting compound, Se-(p-methoxybenzyl)-L-selenocysteine. Glutaselenone diselenide showed a broad absorption band between 270 and 400 nm and circular dichroism bands around 270 nm (positive) and 330 nm (negative), which were attributable to diselenide bond.

Original languageEnglish
Pages (from-to)151-154
Number of pages4
JournalAnalytical Biochemistry
Volume208
Issue number1
DOIs
Publication statusPublished - Jan 1993

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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