Synthesis and characterization of 2H-, 3H- and 4H-azepine: The first observation of the thermal distribution equilibrium of azepines

Kyosuke Satake, Ryoichi Okuda, Michiaki Hashimoto, Yasushi Fujiwara, Izumi Watadani, Hideki Okamoto, Masaru Kimura, Shiro Morosawa

Research output: Contribution to journalArticle

14 Citations (Scopus)


Demethoxycarbonylation of methyl 2,5,-di-tert-butyl-1H-azepine-1- carboxylate using 1,8-diazabicyclo[5.4.0]undec-7-ene gives exclusively two isomers of 3H-azepine derivatives, while methyl 3,6-di-tert-butyl-1H-azepine-1- carboxylate gives a mixture of 2H-, 3H- and 4H-azepine derivatives under the same conditions because of a 1,5-hydrogen shift in the resulting triene system.

Original languageEnglish
Pages (from-to)1154-1156
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number17
Publication statusPublished - Dec 1 1991


ASJC Scopus subject areas

  • Molecular Medicine

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