Synthesis and characterization of 2H-, 3H- and 4H-azepine: The first observation of the thermal distribution equilibrium of azepines

Kyosuke Satake, Ryoichi Okuda, Michiaki Hashimoto, Yasushi Fujiwara, Izumi Watadani, Hideki Okamoto, Masaru Kimura, Shiro Morosawa

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Demethoxycarbonylation of methyl 2,5,-di-tert-butyl-1H-azepine-1- carboxylate using 1,8-diazabicyclo[5.4.0]undec-7-ene gives exclusively two isomers of 3H-azepine derivatives, while methyl 3,6-di-tert-butyl-1H-azepine-1- carboxylate gives a mixture of 2H-, 3H- and 4H-azepine derivatives under the same conditions because of a 1,5-hydrogen shift in the resulting triene system.

Original languageEnglish
Pages (from-to)1154-1156
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number17
DOIs
Publication statusPublished - 1991

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Azepines
Hot Temperature
Observation
Derivatives
Isomers
Hydrogen

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Synthesis and characterization of 2H-, 3H- and 4H-azepine : The first observation of the thermal distribution equilibrium of azepines. / Satake, Kyosuke; Okuda, Ryoichi; Hashimoto, Michiaki; Fujiwara, Yasushi; Watadani, Izumi; Okamoto, Hideki; Kimura, Masaru; Morosawa, Shiro.

In: Journal of the Chemical Society, Chemical Communications, No. 17, 1991, p. 1154-1156.

Research output: Contribution to journalArticle

Satake, Kyosuke ; Okuda, Ryoichi ; Hashimoto, Michiaki ; Fujiwara, Yasushi ; Watadani, Izumi ; Okamoto, Hideki ; Kimura, Masaru ; Morosawa, Shiro. / Synthesis and characterization of 2H-, 3H- and 4H-azepine : The first observation of the thermal distribution equilibrium of azepines. In: Journal of the Chemical Society, Chemical Communications. 1991 ; No. 17. pp. 1154-1156.
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