Synthesis and biological properties of a new series of anti-MRSA β-lactams; 2-(thiazol-2′-ylthio)carbapenems

Makoto Sunagawa, Hiroshi Yamaga, Hisatoshi Shinagawa, Hitoshi Houchigai, Yoshihiro Sumita

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Synthesis and biological properties of a new series of 1β-methyl carbapenems that have been variously substituted thiazol-2′-ylthio side chain on C-2 are described. Amongst synthesized compounds, 4′-arylthiazole derivatives showed potent anti-MRSA activity and the introduction of a quaternary cation was effective to reduce binding to human serum albumin without affecting the anti-MRSA activity.

Original languageEnglish
Pages (from-to)2793-2798
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number23
DOIs
Publication statusPublished - Jan 1 1994
Externally publishedYes

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Lactams
Carbapenems
Methicillin-Resistant Staphylococcus aureus
Serum Albumin
Cations
Derivatives

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and biological properties of a new series of anti-MRSA β-lactams; 2-(thiazol-2′-ylthio)carbapenems. / Sunagawa, Makoto; Yamaga, Hiroshi; Shinagawa, Hisatoshi; Houchigai, Hitoshi; Sumita, Yoshihiro.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 4, No. 23, 01.01.1994, p. 2793-2798.

Research output: Contribution to journalArticle

Sunagawa, Makoto ; Yamaga, Hiroshi ; Shinagawa, Hisatoshi ; Houchigai, Hitoshi ; Sumita, Yoshihiro. / Synthesis and biological properties of a new series of anti-MRSA β-lactams; 2-(thiazol-2′-ylthio)carbapenems. In: Bioorganic and Medicinal Chemistry Letters. 1994 ; Vol. 4, No. 23. pp. 2793-2798.
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