Synthesis and biological properties of a new series of anti-MRSA β-lactams; 2-(thiazol-2′-ylthio)carbapenems

Makoto Sunagawa, Hiroshi Yamaga, Hisatoshi Shinagawa, Hitoshi Houchigai, Yoshihiro Sumita

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Synthesis and biological properties of a new series of 1β-methyl carbapenems that have been variously substituted thiazol-2′-ylthio side chain on C-2 are described. Amongst synthesized compounds, 4′-arylthiazole derivatives showed potent anti-MRSA activity and the introduction of a quaternary cation was effective to reduce binding to human serum albumin without affecting the anti-MRSA activity.

Original languageEnglish
Pages (from-to)2793-2798
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume4
Issue number23
DOIs
Publication statusPublished - Dec 1994

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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