Abstract
We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.
| Original language | English |
|---|---|
| Pages (from-to) | 5614-5617 |
| Number of pages | 4 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 18 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - Oct 15 2008 |
Fingerprint
Keywords
- 5-Alkoxycoumarins
- Artemia salina
- Bursaphelencus xylophilus
- Nematicide
- Oryzias latipes
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Organic Chemistry
- Molecular Medicine
- Molecular Biology
- Clinical Biochemistry
- Biochemistry
Cite this
Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents. / Takaishi, Kazuto; Izumi, Minoru; Baba, Naomichi; Kawazu, Kazuyoshi; Nakajima, Shuhei.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 20, 15.10.2008, p. 5614-5617.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents
AU - Takaishi, Kazuto
AU - Izumi, Minoru
AU - Baba, Naomichi
AU - Kawazu, Kazuyoshi
AU - Nakajima, Shuhei
PY - 2008/10/15
Y1 - 2008/10/15
N2 - We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.
AB - We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.
KW - 5-Alkoxycoumarins
KW - Artemia salina
KW - Bursaphelencus xylophilus
KW - Nematicide
KW - Oryzias latipes
UR - http://www.scopus.com/inward/record.url?scp=53349146601&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=53349146601&partnerID=8YFLogxK
U2 - 10.1016/j.bmcl.2008.08.102
DO - 10.1016/j.bmcl.2008.08.102
M3 - Article
C2 - 18793855
AN - SCOPUS:53349146601
VL - 18
SP - 5614
EP - 5617
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 20
ER -