Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents

Kazuto Takaishi; Minoru Izumi; Naomichi Baba; Kazuyoshi Kawazu; Shuhei Nakajima

doi:10.1016/j.bmcl.2008.08.102

Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents

Kazuto Takaishi, Minoru Izumi, Naomichi Baba, Kazuyoshi Kawazu, Shuhei Nakajima

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.

Original language	English
Pages (from-to)	5614-5617
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	18
Issue number	20
DOIs	https://doi.org/10.1016/j.bmcl.2008.08.102
Publication status	Published - Oct 15 2008

Keywords

5-Alkoxycoumarins
Artemia salina
Bursaphelencus xylophilus
Nematicide
Oryzias latipes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents",

abstract = "We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.",

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T1 - Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents

AU - Takaishi, Kazuto

AU - Izumi, Minoru

AU - Baba, Naomichi

AU - Kawazu, Kazuyoshi

AU - Nakajima, Shuhei

PY - 2008/10/15

Y1 - 2008/10/15

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AB - We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.

KW - 5-Alkoxycoumarins

KW - Artemia salina

KW - Bursaphelencus xylophilus

KW - Nematicide

KW - Oryzias latipes

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