Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents

Kazuto Takaishi, Minoru Izumi, Naomichi Baba, Kazuyoshi Kawazu, Shuhei Nakajima

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.

Original languageEnglish
Pages (from-to)5614-5617
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number20
DOIs
Publication statusPublished - Oct 15 2008

Keywords

  • 5-Alkoxycoumarins
  • Artemia salina
  • Bursaphelencus xylophilus
  • Nematicide
  • Oryzias latipes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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