Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents

Kazuto Takaishi, Minoru Izumi, Naomichi Baba, Kazuyoshi Kawazu, Shuhei Nakajima

Research output: Contribution to journal › Article

16 Citations (Scopus)

Abstract

We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.

Original languageEnglish
Pages (from-to)5614-5617
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number20
DOIs
Publication statusPublished - Oct 15 2008

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Oryzias
Artemia
Derivatives
Salinum
brine

Keywords

  • 5-Alkoxycoumarins
  • Artemia salina
  • Bursaphelencus xylophilus
  • Nematicide
  • Oryzias latipes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents. / Takaishi, Kazuto; Izumi, Minoru; Baba, Naomichi; Kawazu, Kazuyoshi; Nakajima, Shuhei.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 20, 15.10.2008, p. 5614-5617.

Research output: Contribution to journal › Article

Takaishi, K, Izumi, M, Baba, N, Kawazu, K & Nakajima, S 2008, 'Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents', Bioorganic and Medicinal Chemistry Letters, vol. 18, no. 20, pp. 5614-5617. https://doi.org/10.1016/j.bmcl.2008.08.102
Takaishi K, Izumi M, Baba N, Kawazu K, Nakajima S. Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents. Bioorganic and Medicinal Chemistry Letters. 2008 Oct 15;18(20):5614-5617. https://doi.org/10.1016/j.bmcl.2008.08.102
Takaishi, Kazuto ; Izumi, Minoru ; Baba, Naomichi ; Kawazu, Kazuyoshi ; Nakajima, Shuhei. / Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents. In: Bioorganic and Medicinal Chemistry Letters. 2008 ; Vol. 18, No. 20. pp. 5614-5617.
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