Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents

Kazuto Takaishi, Minoru Izumi, Naomichi Baba, Kazuyoshi Kawazu, Shuhei Nakajima

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.

Original languageEnglish
Pages (from-to)5614-5617
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number20
DOIs
Publication statusPublished - Oct 15 2008

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Oryzias
Artemia
Derivatives
Salinum
brine

Keywords

  • 5-Alkoxycoumarins
  • Artemia salina
  • Bursaphelencus xylophilus
  • Nematicide
  • Oryzias latipes

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents. / Takaishi, Kazuto; Izumi, Minoru; Baba, Naomichi; Kawazu, Kazuyoshi; Nakajima, Shuhei.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 18, No. 20, 15.10.2008, p. 5614-5617.

Research output: Contribution to journalArticle

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