Abstract
We synthesized the 4-hydroxy and 4-methoxy analogs of active vitamin D3 (1α,25(OH)2D3, 1) and its C14-epimer with the previtamin D3 form of 14-epi-1α,25(OH)2preD3 (14-epi-pre1). Their vitamin D receptor (VDR) binding affinity and osteocalcin promoter transactivation activity in HOS cells were evaluated, and had lower activity than the natural hormone (1) and 14-epi-pre1, respectively.
Original language | English |
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Pages (from-to) | 1431-1433 |
Number of pages | 3 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 57 |
Issue number | 12 |
DOIs | |
Publication status | Published - Dec 2009 |
Externally published | Yes |
Keywords
- C4-modified seco-steroid
- Osteocalcin
- Previtamin D
- Vitamin D
- Vitamin D receptor
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery