Synthesis and biological evaluation of 4-substituted vitamin D and 14-epi-previtamin D analogs

Daisuke Sawada; Yuya Tsukuda; Hiroshi Saito; Ken Ichiro Takagi; Kyouhei Horie; Eiji Ochiai; Kazuya Takenouchi; Atsushi Kittaka

doi:10.1248/cpb.57.1431

Synthesis and biological evaluation of 4-substituted vitamin D and 14-epi-previtamin D analogs

Daisuke Sawada, Yuya Tsukuda, Hiroshi Saito, Ken Ichiro Takagi, Kyouhei Horie, Eiji Ochiai, Kazuya Takenouchi, Atsushi Kittaka

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

We synthesized the 4-hydroxy and 4-methoxy analogs of active vitamin D3 (1α,25(OH)₂D₃, 1) and its C14-epimer with the previtamin D3 form of 14-epi-1α,25(OH)₂preD₃ (14-epi-pre1). Their vitamin D receptor (VDR) binding affinity and osteocalcin promoter transactivation activity in HOS cells were evaluated, and had lower activity than the natural hormone (1) and 14-epi-pre1, respectively.

Original language	English
Pages (from-to)	1431-1433
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	57
Issue number	12
DOIs	https://doi.org/10.1248/cpb.57.1431
Publication status	Published - Dec 1 2009
Externally published	Yes

Keywords

C4-modified seco-steroid
Osteocalcin
Previtamin D
Vitamin D
Vitamin D receptor

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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Sawada, D., Tsukuda, Y., Saito, H., Takagi, K. I., Horie, K., Ochiai, E., Takenouchi, K., & Kittaka, A. (2009). Synthesis and biological evaluation of 4-substituted vitamin D and 14-epi-previtamin D analogs. Chemical and Pharmaceutical Bulletin, 57(12), 1431-1433. https://doi.org/10.1248/cpb.57.1431

Synthesis and biological evaluation of 4-substituted vitamin D and 14-epi-previtamin D analogs. / Sawada, Daisuke; Tsukuda, Yuya; Saito, Hiroshi; Takagi, Ken Ichiro; Horie, Kyouhei; Ochiai, Eiji; Takenouchi, Kazuya; Kittaka, Atsushi.

In: Chemical and Pharmaceutical Bulletin, Vol. 57, No. 12, 01.12.2009, p. 1431-1433.

Research output: Contribution to journal › Article

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