Abstract
Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 1075-1077 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Mar 24 2003 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry
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Cite this
Cheng, Q., Kiyota, H., Yamaguchi, M., Horiguchi, T., & Oritani, T. (2003). Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues. Bioorganic and Medicinal Chemistry Letters, 13(6), 1075-1077. https://doi.org/10.1016/S0960-894X(03)00054-4