Abstract
Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 1075-1077 |
| Number of pages | 3 |
| Journal | Bioorganic and Medicinal Chemistry Letters |
| Volume | 13 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Mar 24 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues. / Cheng, Qian; Kiyota, Hiromasa; Yamaguchi, Marina; Horiguchi, Tohru; Oritani, Takayuki.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 6, 24.03.2003, p. 1075-1077.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues
AU - Cheng, Qian
AU - Kiyota, Hiromasa
AU - Yamaguchi, Marina
AU - Horiguchi, Tohru
AU - Oritani, Takayuki
PY - 2003/3/24
Y1 - 2003/3/24
N2 - Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.
AB - Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.
UR - http://www.scopus.com/inward/record.url?scp=0037463753&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037463753&partnerID=8YFLogxK
U2 - 10.1016/S0960-894X(03)00054-4
DO - 10.1016/S0960-894X(03)00054-4
M3 - Article
C2 - 12643915
AN - SCOPUS:0037463753
VL - 13
SP - 1075
EP - 1077
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 6
ER -