Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues

Qian Cheng, Hiromasa Kiyota, Marina Yamaguchi, Tohru Horiguchi, Takayuki Oritani

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Three novel 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues were synthesized through a convenient route that employed hydroboration-amination and intramolecular SN2-type substitution reaction from a natural taxoid taxinine. All analogues have been tested for cytotoxicity against three human tumor cell lines. None of them showed remarkable cytotoxicity compared to paclitaxel against tested tumor cell lines.

Original languageEnglish
Pages (from-to)1075-1077
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number6
DOIs
Publication statusPublished - Mar 24 2003
Externally publishedYes

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Cytotoxicity
Paclitaxel
Tumor Cell Line
Tumors
Cells
Amination
Taxoids
Substitution reactions
azetidine
taxinine

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues. / Cheng, Qian; Kiyota, Hiromasa; Yamaguchi, Marina; Horiguchi, Tohru; Oritani, Takayuki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 6, 24.03.2003, p. 1075-1077.

Research output: Contribution to journalArticle

Cheng, Qian ; Kiyota, Hiromasa ; Yamaguchi, Marina ; Horiguchi, Tohru ; Oritani, Takayuki. / Synthesis and biological evaluation of 4-deacetoxy-1,7-dideoxy azetidine paclitaxel analogues. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 6. pp. 1075-1077.
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