Synthesis and biological activity of mycalolide analogs

Kiyotake Suenaga, Tomoyuki Kimura, Takeshi Kuroda, Keita Matsui, Saori Miya, Satomi Kuribayashi, Akira Sakakura, Hideo Kigoshi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Mycalolide analog 4, consisting only of the side chain of mycalolide B (2), a trisoxazole macrolide of marine origin, was stereoselectively synthesized using Roush crotylboration, an Evans aldol reaction, and a Paterson aldol reaction as key steps. The analog 4 was found to have strong actin-depolymerizing activity.

Original languageEnglish
Pages (from-to)8278-8290
Number of pages13
JournalTetrahedron
Volume62
Issue number35
DOIs
Publication statusPublished - Aug 28 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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