Synthesis and biological activity of fatty acid derivatives of quinine

Naokazu Kumura, Minoru Izumi, Shuhei Nakajima, Sakayu Shimizu, Hye-Sook Kim, Yusuke Wataya, Naomichi Baba

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Derivatives of quinine with fatty acids including polyunsaturated fatty acids were prepared. They showed moderate antimalarial activity as compared with quinine itself using Plasmodium falciparum. The activities were not dependent on whether the fatty acyl group was saturated or unsaturated. On the other hand, the derivatives showed significantly higher cytotoxicity against a mammary tumor cell line FM3A than quinine itself. Calculating from these data, an acetyl derivative of quinine with the shortest acyl group was found to give the highest selectivity.

Original languageEnglish
Pages (from-to)2250-2253
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume69
Issue number11
DOIs
Publication statusPublished - 2005

Fingerprint

quinine
Quinine
Bioactivity
Fatty acids
bioactive properties
Fatty Acids
chemical derivatives
Derivatives
fatty acids
synthesis
Polyunsaturated fatty acids
Cytotoxicity
antimalarials
Tumors
mammary neoplasms (animal)
Antimalarials
Plasmodium falciparum
Tumor Cell Line
Unsaturated Fatty Acids
Cells

Keywords

  • Antimalarial activity
  • Fatty acid
  • Plasmodium falciparum
  • Quinine

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science

Cite this

Synthesis and biological activity of fatty acid derivatives of quinine. / Kumura, Naokazu; Izumi, Minoru; Nakajima, Shuhei; Shimizu, Sakayu; Kim, Hye-Sook; Wataya, Yusuke; Baba, Naomichi.

In: Bioscience, Biotechnology and Biochemistry, Vol. 69, No. 11, 2005, p. 2250-2253.

Research output: Contribution to journalArticle

Kumura, Naokazu ; Izumi, Minoru ; Nakajima, Shuhei ; Shimizu, Sakayu ; Kim, Hye-Sook ; Wataya, Yusuke ; Baba, Naomichi. / Synthesis and biological activity of fatty acid derivatives of quinine. In: Bioscience, Biotechnology and Biochemistry. 2005 ; Vol. 69, No. 11. pp. 2250-2253.
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