Abstract
Derivatives of quinine with fatty acids including polyunsaturated fatty acids were prepared. They showed moderate antimalarial activity as compared with quinine itself using Plasmodium falciparum. The activities were not dependent on whether the fatty acyl group was saturated or unsaturated. On the other hand, the derivatives showed significantly higher cytotoxicity against a mammary tumor cell line FM3A than quinine itself. Calculating from these data, an acetyl derivative of quinine with the shortest acyl group was found to give the highest selectivity.
| Original language | English |
|---|---|
| Pages (from-to) | 2250-2253 |
| Number of pages | 4 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 69 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2005 |
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Keywords
- Antimalarial activity
- Fatty acid
- Plasmodium falciparum
- Quinine
ASJC Scopus subject areas
- Bioengineering
- Biotechnology
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry (miscellaneous)
- Applied Microbiology and Biotechnology
- Food Science
Cite this
Synthesis and biological activity of fatty acid derivatives of quinine. / Kumura, Naokazu; Izumi, Minoru; Nakajima, Shuhei; Shimizu, Sakayu; Kim, Hye-Sook; Wataya, Yusuke; Baba, Naomichi.
In: Bioscience, Biotechnology and Biochemistry, Vol. 69, No. 11, 2005, p. 2250-2253.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and biological activity of fatty acid derivatives of quinine
AU - Kumura, Naokazu
AU - Izumi, Minoru
AU - Nakajima, Shuhei
AU - Shimizu, Sakayu
AU - Kim, Hye-Sook
AU - Wataya, Yusuke
AU - Baba, Naomichi
PY - 2005
Y1 - 2005
N2 - Derivatives of quinine with fatty acids including polyunsaturated fatty acids were prepared. They showed moderate antimalarial activity as compared with quinine itself using Plasmodium falciparum. The activities were not dependent on whether the fatty acyl group was saturated or unsaturated. On the other hand, the derivatives showed significantly higher cytotoxicity against a mammary tumor cell line FM3A than quinine itself. Calculating from these data, an acetyl derivative of quinine with the shortest acyl group was found to give the highest selectivity.
AB - Derivatives of quinine with fatty acids including polyunsaturated fatty acids were prepared. They showed moderate antimalarial activity as compared with quinine itself using Plasmodium falciparum. The activities were not dependent on whether the fatty acyl group was saturated or unsaturated. On the other hand, the derivatives showed significantly higher cytotoxicity against a mammary tumor cell line FM3A than quinine itself. Calculating from these data, an acetyl derivative of quinine with the shortest acyl group was found to give the highest selectivity.
KW - Antimalarial activity
KW - Fatty acid
KW - Plasmodium falciparum
KW - Quinine
UR - http://www.scopus.com/inward/record.url?scp=28244468426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28244468426&partnerID=8YFLogxK
U2 - 10.1271/bbb.69.2250
DO - 10.1271/bbb.69.2250
M3 - Article
C2 - 16306714
AN - SCOPUS:28244468426
VL - 69
SP - 2250
EP - 2253
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 11
ER -