Abstract
The tumor promoter (–)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group. Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.
Original language | English |
---|---|
Pages (from-to) | 1415-1417 |
Number of pages | 3 |
Journal | Bioscience, Biotechnology and Biochemistry |
Volume | 61 |
Issue number | 8 |
DOIs | |
Publication status | Published - Jan 1997 |
Externally published | Yes |
Keywords
- (–)-indolactam-V
- Conformation
- Indolactone-V
- Protein kinase C
- Teleocidin
- Tumor promoter
ASJC Scopus subject areas
- Biotechnology
- Analytical Chemistry
- Biochemistry
- Applied Microbiology and Biotechnology
- Molecular Biology
- Organic Chemistry