Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.

Y. Nakagawa, K. Irie, Yoshimasa Nakamura, H. Ohigashi, H. Hayashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The tumor promoter (-)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group. Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.

Original languageEnglish
Pages (from-to)1415-1417
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume61
Issue number8
Publication statusPublished - Aug 1997
Externally publishedYes

Fingerprint

Lactones
amides
Bioactivity
lactones
Amides
Carcinogens
bioactive properties
Tumors
neoplasms
synthesis
Conformations
isomerization
Isomerization
indolactone V
indolactam V

ASJC Scopus subject areas

  • Bioengineering
  • Biotechnology
  • Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Chemistry (miscellaneous)
  • Applied Microbiology and Biotechnology
  • Food Science

Cite this

Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V. / Nakagawa, Y.; Irie, K.; Nakamura, Yoshimasa; Ohigashi, H.; Hayashi, H.

In: Bioscience, Biotechnology and Biochemistry, Vol. 61, No. 8, 08.1997, p. 1415-1417.

Research output: Contribution to journalArticle

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