Abstract
The tumor promoter (-)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group. Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.
| Original language | English |
|---|---|
| Pages (from-to) | 1415-1417 |
| Number of pages | 3 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 61 |
| Issue number | 8 |
| Publication status | Published - Aug 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Bioengineering
- Biotechnology
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry (miscellaneous)
- Applied Microbiology and Biotechnology
- Food Science
Cite this
Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V. / Nakagawa, Y.; Irie, K.; Nakamura, Yoshimasa; Ohigashi, H.; Hayashi, H.
In: Bioscience, Biotechnology and Biochemistry, Vol. 61, No. 8, 08.1997, p. 1415-1417.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V.
AU - Nakagawa, Y.
AU - Irie, K.
AU - Nakamura, Yoshimasa
AU - Ohigashi, H.
AU - Hayashi, H.
PY - 1997/8
Y1 - 1997/8
N2 - The tumor promoter (-)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group. Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.
AB - The tumor promoter (-)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group. Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0031201509&partnerID=8YFLogxK
M3 - Article
C2 - 9301127
AN - SCOPUS:0031201509
VL - 61
SP - 1415
EP - 1417
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 8
ER -