Synthesis and Biological Activities of Indolactone-V, the Lactone Analogue of the Tumor Promoter (–)-Indolactam-V

Yu Nakagawa, Kazuhiro Irie, Yoshimasa Nakamura, Hajime Ohigashi, Hideo Hayashi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The tumor promoter (–)-indolactam-V (1) exists in two stable conformers (twist and sofa) due to isomerization of the amide group. Indolactone-V (2), the lactone analogue of 1, has been synthesized to investigate the effects of the amide group on its conformation and biological activities. Indolactone-V (2) existed only as the inactive sofa-like conformer, indicating that the amide group of 1 plays a critical role in formation of the active twist conformation.

Original languageEnglish
Pages (from-to)1415-1417
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume61
Issue number8
DOIs
Publication statusPublished - Jan 1997
Externally publishedYes

Keywords

  • (–)-indolactam-V
  • Conformation
  • Indolactone-V
  • Protein kinase C
  • Teleocidin
  • Tumor promoter

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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