Synthesis and antitumor activity of tropolone derivatives. 5

Masatoshi Yamato, Kuniko Hashigaki, Junko Sakai, Yasuo Takeuchi, Shigeru Tsukagoshi, Tazuko Tashiro, Takashi Tsuruo

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Abstract

As part of a study on the structure-activity relationship of antitumor-active tropolone derivatives, a series of bistropone analogues, related to potently active bistropolone 1a, were synthesized and tested for their antitumor activity in in vitro (KB cell) and in vivo (leukemia P388 in mice) systems. The methoxytropones 3 and 5, hydroxytropothione 10, and (N-methylamino)tropones 12 and 13 were inactive in both systems. Methoxytropone 6 exhibited weak activity, whose potency was equal to that of monotropolone 2a.

Original languageEnglish
Pages (from-to)1245-1248
Number of pages4
JournalJournal of Medicinal Chemistry
Volume30
Issue number7
Publication statusPublished - 1987

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ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Yamato, M., Hashigaki, K., Sakai, J., Takeuchi, Y., Tsukagoshi, S., Tashiro, T., & Tsuruo, T. (1987). Synthesis and antitumor activity of tropolone derivatives. 5. Journal of Medicinal Chemistry, 30(7), 1245-1248.