Synthesis and Antitumor Activity of Fused Quinoline Derivatives: III: 1,2) Novel N-Glycosylamino-indolo[ 3,2-b]quinolines

Yasuo Takeuchi, Ming rong Chang, Kuniko Hashigaki, Tazuko Tashiro, Masatoshi Yamato, Takashi Tsuruo, Shigeru Tsukagoshi

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Novel indolo[3,2-£]quinolines (lb—k), having a nitro, amino, acetamido, methanesulfonamido, or glycosylamino group at the 2, 7, or 8-position, were prepared and their antitumor activities against P388 leukemia in mice were examined. The 7-galactopyranosylamino derivative (lg) showed the most potent activity (optimal dose = 25 mg/kg, T/C>333%, cure rate 5/6).

Original languageEnglish
Pages (from-to)1481-1485
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number6
DOIs
Publication statusPublished - Jan 1 1992

Keywords

  • P388 leukemia
  • antitumor activity
  • glycosylation
  • indolo[3,2-b]quinoline

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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