Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines

Yasuo Takeuchi, Toshiaki Oda, Ming Rong Chang, Yoko Okamoto, Junko Ono, Yoko Oda, Kyoko Harada, Kuniko Hashigaki, Masatoshi Yamato

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21 Citations (Scopus)

Abstract

Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.

Original languageEnglish
Pages (from-to)406-411
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number2
DOIs
Publication statusPublished - Feb 1997

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Keywords

  • antitumor activity
  • indolo[3,2-b]quinoline
  • quinone diimine
  • structure activity relationship
  • synthesis

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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