Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines

Yasuo Takeuchi, Toshiaki Oda, Ming Rong Chang, Yoko Okamoto, Junko Ono, Yoko Oda, Kyoko Harada, Kuniko Hashigaki, Masatoshi Yamato

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.

Original languageEnglish
Pages (from-to)406-411
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number2
Publication statusPublished - Feb 1997

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Quinolines
Amines
Derivatives
Leukemia P388
quinoline

Keywords

  • antitumor activity
  • indolo[3,2-b]quinoline
  • quinone diimine
  • structure activity relationship
  • synthesis

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines. / Takeuchi, Yasuo; Oda, Toshiaki; Chang, Ming Rong; Okamoto, Yoko; Ono, Junko; Oda, Yoko; Harada, Kyoko; Hashigaki, Kuniko; Yamato, Masatoshi.

In: Chemical and Pharmaceutical Bulletin, Vol. 45, No. 2, 02.1997, p. 406-411.

Research output: Contribution to journalArticle

Takeuchi, Y, Oda, T, Chang, MR, Okamoto, Y, Ono, J, Oda, Y, Harada, K, Hashigaki, K & Yamato, M 1997, 'Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines', Chemical and Pharmaceutical Bulletin, vol. 45, no. 2, pp. 406-411.
Takeuchi, Yasuo ; Oda, Toshiaki ; Chang, Ming Rong ; Okamoto, Yoko ; Ono, Junko ; Oda, Yoko ; Harada, Kyoko ; Hashigaki, Kuniko ; Yamato, Masatoshi. / Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines. In: Chemical and Pharmaceutical Bulletin. 1997 ; Vol. 45, No. 2. pp. 406-411.
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