Abstract
Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.
| Original language | English |
|---|---|
| Pages (from-to) | 406-411 |
| Number of pages | 6 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 45 |
| Issue number | 2 |
| Publication status | Published - Feb 1997 |
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Keywords
- antitumor activity
- indolo[3,2-b]quinoline
- quinone diimine
- structure activity relationship
- synthesis
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Pharmacology
Cite this
Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines. / Takeuchi, Yasuo; Oda, Toshiaki; Chang, Ming Rong; Okamoto, Yoko; Ono, Junko; Oda, Yoko; Harada, Kyoko; Hashigaki, Kuniko; Yamato, Masatoshi.
In: Chemical and Pharmaceutical Bulletin, Vol. 45, No. 2, 02.1997, p. 406-411.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines
AU - Takeuchi, Yasuo
AU - Oda, Toshiaki
AU - Chang, Ming Rong
AU - Okamoto, Yoko
AU - Ono, Junko
AU - Oda, Yoko
AU - Harada, Kyoko
AU - Hashigaki, Kuniko
AU - Yamato, Masatoshi
PY - 1997/2
Y1 - 1997/2
N2 - Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.
AB - Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.
KW - antitumor activity
KW - indolo[3,2-b]quinoline
KW - quinone diimine
KW - structure activity relationship
KW - synthesis
UR - http://www.scopus.com/inward/record.url?scp=0030968041&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030968041&partnerID=8YFLogxK
M3 - Article
C2 - 9118455
AN - SCOPUS:0030968041
VL - 45
SP - 406
EP - 411
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 2
ER -