Abstract
Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.
| Original language | English |
|---|---|
| Pages (from-to) | 406-411 |
| Number of pages | 6 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Feb 1997 |
Keywords
- antitumor activity
- indolo[3,2-b]quinoline
- quinone diimine
- structure activity relationship
- synthesis
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Takeuchi, Y., Oda, T., Chang, M. R., Okamoto, Y., Ono, J., Oda, Y., Harada, K., Hashigaki, K., & Yamato, M. (1997). Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines. Chemical and Pharmaceutical Bulletin, 45(2), 406-411. https://doi.org/10.1248/cpb.45.406