Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines

Yasuo Takeuchi; Toshiaki Oda; Ming Rong Chang; Yoko Okamoto; Junko Ono; Yoko Oda; Kyoko Harada; Kuniko Hashigaki; Masatoshi Yamato

doi:10.1248/cpb.45.406

Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines

Yasuo Takeuchi, Toshiaki Oda, Ming Rong Chang, Yoko Okamoto, Junko Ono, Yoko Oda, Kyoko Harada, Kuniko Hashigaki, Masatoshi Yamato

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.

Original language	English
Pages (from-to)	406-411
Number of pages	6
Journal	Chemical and Pharmaceutical Bulletin
Volume	45
Issue number	2
DOIs	https://doi.org/10.1248/cpb.45.406
Publication status	Published - Feb 1997

Keywords

antitumor activity
indolo[3,2-b]quinoline
quinone diimine
structure activity relationship
synthesis

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.45.406

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abstract = "Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.",

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AU - Takeuchi, Yasuo

AU - Oda, Toshiaki

AU - Chang, Ming Rong

AU - Okamoto, Yoko

AU - Ono, Junko

AU - Oda, Yoko

AU - Harada, Kyoko

AU - Hashigaki, Kuniko

AU - Yamato, Masatoshi

PY - 1997/2

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AB - Indolo[3,2-b]quinoline derivatives (1) having various amine moieties were prepared and their antitumor activities against P388 leukemia in mice were evaluated, for the purpose of gaining an insight into the role of the amine moiety in the antitumor activity and searching for an effective amine moiety. Introduction of a methylene group between the phenyl group and amino or methanesulfonamido group resulted in decrease or loss of activity.

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KW - indolo[3,2-b]quinoline

KW - quinone diimine

KW - structure activity relationship

KW - synthesis

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Synthesis and antitumor activity of fused quinoline derivatives. IV. Novel 11-aminoindolo[3,2-b]quinolines

Abstract

Keywords

ASJC Scopus subject areas

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