Abstract
Novel indolo[3,2-£]quinoline derivatives (lc—f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound la, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (Id), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (If) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) >330%, cure = 5/6).
| Original language | English |
|---|---|
| Pages (from-to) | 528-530 |
| Number of pages | 3 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 40 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Jan 1 1992 |
Keywords
- 2-6]quinoline antitumor activity P388 leukemia synthesis molecular modification hydroxy group methoxy group
- indolo[3
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Yamato, M., Takeuchi, Y., Chang, M. R., & Hashigaki, K. (1992). Synthesis and Antitumor Activity of Fused Quinoline Derivatives: II: Novel 4- and 7-Hydroxyindolo-[3,2-A] quinolines. Chemical and Pharmaceutical Bulletin, 40(2), 528-530. https://doi.org/10.1248/cpb.40.528