Synthesis and antitumor activity of fused quinoline derivatives. II. Novel 4- and 7-hydroxyindolo-[3,2-b]quinolines

M. Yamato, Yasuo Takeuchi, M. Chang, K. Hashigaki

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18 Citations (Scopus)


Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) > 330%, cure = 5/6).

Original languageEnglish
Pages (from-to)528-530
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Issue number2
Publication statusPublished - 1992


ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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