Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) > 330%, cure = 5/6).
|Number of pages||3|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 1992|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery