Abstract
Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) > 330%, cure = 5/6).
| Original language | English |
|---|---|
| Pages (from-to) | 528-530 |
| Number of pages | 3 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 40 |
| Issue number | 2 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
Synthesis and antitumor activity of fused quinoline derivatives. II. Novel 4- and 7-hydroxyindolo-[3,2-b]quinolines. / Yamato, M.; Takeuchi, Yasuo; Chang, M.; Hashigaki, K.
In: Chemical and Pharmaceutical Bulletin, Vol. 40, No. 2, 1992, p. 528-530.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Synthesis and antitumor activity of fused quinoline derivatives. II. Novel 4- and 7-hydroxyindolo-[3,2-b]quinolines
AU - Yamato, M.
AU - Takeuchi, Yasuo
AU - Chang, M.
AU - Hashigaki, K.
PY - 1992
Y1 - 1992
N2 - Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) > 330%, cure = 5/6).
AB - Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) > 330%, cure = 5/6).
UR - http://www.scopus.com/inward/record.url?scp=0026552164&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026552164&partnerID=8YFLogxK
M3 - Article
C2 - 1606653
AN - SCOPUS:0026552164
VL - 40
SP - 528
EP - 530
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 2
ER -