Abstract
Novel indolo[3,2-b]quinoline derivatives (1c-f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound 1a, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (1d), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (1f) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) > 330%, cure = 5/6).
| Original language | English |
|---|---|
| Pages (from-to) | 528-530 |
| Number of pages | 3 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 40 |
| Issue number | 2 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Chemistry(all)
- Organic Chemistry
- Drug Discovery
- Pharmacology
Cite this
Yamato, M., Takeuchi, Y., Chang, M., & Hashigaki, K. (1992). Synthesis and antitumor activity of fused quinoline derivatives. II. Novel 4- and 7-hydroxyindolo-[3,2-b]quinolines. Chemical and Pharmaceutical Bulletin, 40(2), 528-530.