Synthesis and Antitumor Activity of Fused Quinoline Derivatives: II: Novel 4- and 7-Hydroxyindolo-[3,2-A] quinolines

Masatoshi Yamato; Yasuo Takeuchi; Ming rong Chang; Kuniko Hashigaki

doi:10.1248/cpb.40.528

Synthesis and Antitumor Activity of Fused Quinoline Derivatives: II: Novel 4- and 7-Hydroxyindolo-[3,2-A] quinolines

Masatoshi Yamato, Yasuo Takeuchi, Ming rong Chang, Kuniko Hashigaki

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Novel indolo[3,2-£]quinoline derivatives (lc—f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound la, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (Id), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (If) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) >330%, cure = 5/6).

Original language	English
Pages (from-to)	528-530
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	40
Issue number	2
DOIs	https://doi.org/10.1248/cpb.40.528
Publication status	Published - 1992

Keywords

2-6]quinoline antitumor activity P388 leukemia synthesis molecular modification hydroxy group methoxy group
indolo[3

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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abstract = "Novel indolo[3,2-£]quinoline derivatives (lc—f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound la, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (Id), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (If) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) >330%, cure = 5/6).",

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AU - Hashigaki, Kuniko

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