TY - JOUR
T1 - Synthesis and Antitumor Activity of Fused Quinoline Derivatives
T2 - II: Novel 4- and 7-Hydroxyindolo-[3,2-A] quinolines
AU - Yamato, Masatoshi
AU - Takeuchi, Yasuo
AU - Chang, Ming rong
AU - Hashigaki, Kuniko
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1992
Y1 - 1992
N2 - Novel indolo[3,2-£]quinoline derivatives (lc—f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound la, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (Id), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (If) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) >330%, cure = 5/6).
AB - Novel indolo[3,2-£]quinoline derivatives (lc—f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound la, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (Id), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (If) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) >330%, cure = 5/6).
KW - 2-6]quinoline antitumor activity P388 leukemia synthesis molecular modification hydroxy group methoxy group
KW - indolo[3
UR - http://www.scopus.com/inward/record.url?scp=0026552164&partnerID=8YFLogxK
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U2 - 10.1248/cpb.40.528
DO - 10.1248/cpb.40.528
M3 - Article
C2 - 1606653
AN - SCOPUS:0026552164
VL - 40
SP - 528
EP - 530
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 2
ER -