Synthesis and Antitumor Activity of Fused Quinoline Derivatives: II: Novel 4- and 7-Hydroxyindolo-[3,2-A] quinolines

Masatoshi Yamato, Yasuo Takeuchi, Ming rong Chang, Kuniko Hashigaki

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Novel indolo[3,2-£]quinoline derivatives (lc—f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound la, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (Id), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (If) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) >330%, cure = 5/6).

Original languageEnglish
Pages (from-to)528-530
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume40
Issue number2
DOIs
Publication statusPublished - Jan 1 1992

Keywords

  • 2-6]quinoline antitumor activity P388 leukemia synthesis molecular modification hydroxy group methoxy group
  • indolo[3

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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