Novel indolo[3,2-£]quinoline derivatives (lc—f), which carried a methoxy or a hydroxy group at the 4- or 7-position of the lead compound la, were prepared and their antitumor activities against P388 in mice were examined. Except for the 4-hydroxy derivative (Id), these showed remarkably potent activity. Among these compounds, the 7-hydroxy derivative (If) was the most potent one (optimal dose = 50 mg/kg, the median survival time of treated group/control group (T/C) >330%, cure = 5/6).
- 2-6]quinoline antitumor activity P388 leukemia synthesis molecular modification hydroxy group methoxy group
ASJC Scopus subject areas
- Drug Discovery