Synthesis and antitumor activity of 7-(w-glycosylamino)-indolo[3,2-6]quinolines

Yasuo Takeuchi, Ming rong Chang, Kuniko Hashigaki, Masatoshi Yamato

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Novel indolo[3,2-6]quinolines (l d-g), introduced at the 7-position with an N- glycosylamino group, were prepared and their antitumor activities against leukemia P388 in mice were examined. The N-Galactopyranosylamino derivative (le) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C > 333%, cure 5/6) than lead compound la.

Original languageEnglish
Pages (from-to)1629-1631
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number6
DOIs
Publication statusPublished - Jan 1 1991

Keywords

  • 2-6]quinoline glycosylation antitumor activity intercalation P388 leukemia
  • indolo[3

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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