Synthesis and antitumor activity of 7-(N-glycosylamino)-indolo[3,2-b]quinolines

Yasuo Takeuchi, M. R. Chang, K. Hashigaki, M. Yamato

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Abstract

Novel indolo[3,2-b]quinolines (1d-g), introduced at the 7-position with an N-glycosylamino group, were prepared and their antitumor activities against leukemia P355 in mice were examined. The N-galactopyranosylamino derivative (1e) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C > 333%, cure 5/6) than lead compound 1a.

Original languageEnglish
Pages (from-to)1629-1631
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number6
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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