Novel indolo[3,2-b]quinolines (1d-g), introduced at the 7-position with an N-glycosylamino group, were prepared and their antitumor activities against leukemia P355 in mice were examined. The N-galactopyranosylamino derivative (1e) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C > 333%, cure 5/6) than lead compound 1a.
|Number of pages||3|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 1991|
ASJC Scopus subject areas
- Organic Chemistry
- Drug Discovery