Synthesis and antitumor activity of 7-(N-glycosylamino)-indolo[3,2-b]quinolines

Yasuo Takeuchi, M. R. Chang, K. Hashigaki, M. Yamato

Research output: Contribution to journalArticle

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Abstract

Novel indolo[3,2-b]quinolines (1d-g), introduced at the 7-position with an N-glycosylamino group, were prepared and their antitumor activities against leukemia P355 in mice were examined. The N-galactopyranosylamino derivative (1e) was a much more potent anti-leukemia compound (optimal dose = 25 mg/kg, T/C > 333%, cure 5/6) than lead compound 1a.

Original languageEnglish
Pages (from-to)1629-1631
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume39
Issue number6
Publication statusPublished - 1991

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Quinolines
Lead compounds
Leukemia
Derivatives

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Synthesis and antitumor activity of 7-(N-glycosylamino)-indolo[3,2-b]quinolines. / Takeuchi, Yasuo; Chang, M. R.; Hashigaki, K.; Yamato, M.

In: Chemical and Pharmaceutical Bulletin, Vol. 39, No. 6, 1991, p. 1629-1631.

Research output: Contribution to journalArticle

Takeuchi, Yasuo ; Chang, M. R. ; Hashigaki, K. ; Yamato, M. / Synthesis and antitumor activity of 7-(N-glycosylamino)-indolo[3,2-b]quinolines. In: Chemical and Pharmaceutical Bulletin. 1991 ; Vol. 39, No. 6. pp. 1629-1631.
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