Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi; Takayuki Oritani; Hiromasa Kiyota

doi:10.1016/S0040-4020(03)00048-6

Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

Original language	English
Pages (from-to)	1529-1538
Number of pages	10
Journal	Tetrahedron
Volume	59
Issue number	9
DOIs	https://doi.org/10.1016/S0040-4020(03)00048-6
Publication status	Published - Feb 24 2003
Externally published	Yes

Keywords

Antitumor activity
Taxinine
Taxol
m-azidobenzoyl

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4020(03)00048-6

Cite this

@article{326b980ba9e44e4a8120263afe867abf,

title = "Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine",

abstract = "2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.",

keywords = "Antitumor activity, Taxinine, Taxol, m-azidobenzoyl",

author = "Tohru Horiguchi and Takayuki Oritani and Hiromasa Kiyota",

year = "2003",

month = feb,

day = "24",

doi = "10.1016/S0040-4020(03)00048-6",

language = "English",

volume = "59",

pages = "1529--1538",

journal = "Tetrahedron",

issn = "0040-4020",

publisher = "Elsevier Limited",

number = "9",

}

TY - JOUR

T1 - Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

AU - Horiguchi, Tohru

AU - Oritani, Takayuki

AU - Kiyota, Hiromasa

PY - 2003/2/24

Y1 - 2003/2/24

N2 - 2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

AB - 2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

KW - Antitumor activity

KW - Taxinine

KW - Taxol

KW - m-azidobenzoyl

UR - http://www.scopus.com/inward/record.url?scp=0037463482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037463482&partnerID=8YFLogxK

U2 - 10.1016/S0040-4020(03)00048-6

DO - 10.1016/S0040-4020(03)00048-6

M3 - Article

AN - SCOPUS:0037463482

VL - 59

SP - 1529

EP - 1538

JO - Tetrahedron

JF - Tetrahedron

SN - 0040-4020

IS - 9

ER -

Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this