Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi; Takayuki Oritani; Hiromasa Kiyota

doi:10.1016/S0040-4020(03)00048-6

Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

Original language	English
Pages (from-to)	1529-1538
Number of pages	10
Journal	Tetrahedron
Volume	59
Issue number	9
DOIs	https://doi.org/10.1016/S0040-4020(03)00048-6
Publication status	Published - Feb 24 2003
Externally published	Yes

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Keywords

Antitumor activity
m-azidobenzoyl
Taxinine
Taxol

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

Cite this

Horiguchi, T., Oritani, T., & Kiyota, H. (2003). Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine. Tetrahedron, 59(9), 1529-1538. https://doi.org/10.1016/S0040-4020(03)00048-6

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10.1016/S0040-4020(03)00048-6