Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

Original languageEnglish
Pages (from-to)1529-1538
Number of pages10
JournalTetrahedron
Volume59
Issue number9
DOIs
Publication statusPublished - Feb 24 2003
Externally publishedYes

Keywords

  • Antitumor activity
  • Taxinine
  • Taxol
  • m-azidobenzoyl

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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