Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi; Takayuki Oritani; Hiromasa Kiyota

doi:10.1016/S0040-4020(03)00048-6

Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

Original language	English
Pages (from-to)	1529-1538
Number of pages	10
Journal	Tetrahedron
Volume	59
Issue number	9
DOIs	https://doi.org/10.1016/S0040-4020(03)00048-6
Publication status	Published - Feb 24 2003
Externally published	Yes

Keywords

Antitumor activity
Taxinine
Taxol
m-azidobenzoyl

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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title = "Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine",

abstract = "2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.",

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AU - Horiguchi, Tohru

AU - Oritani, Takayuki

AU - Kiyota, Hiromasa

PY - 2003/2/24

Y1 - 2003/2/24

N2 - 2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

AB - 2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

KW - Antitumor activity

KW - Taxinine

KW - Taxol

KW - m-azidobenzoyl

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