Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine

Tohru Horiguchi, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journal › Article

10 Citations (Scopus)

Abstract

2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.

Original languageEnglish
Pages (from-to)1529-1538
Number of pages10
JournalTetrahedron
Volume59
Issue number9
DOIs
Publication statusPublished - Feb 24 2003
Externally publishedYes

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Hydroxyl Radical
baccatin III
taxinine

Keywords

  • Antitumor activity
  • m-azidobenzoyl
  • Taxinine
  • Taxol

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

Cite this

Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine. / Horiguchi, Tohru; Oritani, Takayuki; Kiyota, Hiromasa.

In: Tetrahedron, Vol. 59, No. 9, 24.02.2003, p. 1529-1538.

Research output: Contribution to journal › Article

Horiguchi, T, Oritani, T & Kiyota, H 2003, 'Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine', Tetrahedron, vol. 59, no. 9, pp. 1529-1538. https://doi.org/10.1016/S0040-4020(03)00048-6
Horiguchi T, Oritani T, Kiyota H. Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine. Tetrahedron. 2003 Feb 24;59(9):1529-1538. https://doi.org/10.1016/S0040-4020(03)00048-6
Horiguchi, Tohru ; Oritani, Takayuki ; Kiyota, Hiromasa. / Synthesis and antitumor activity of 2-(m-substituted-benzoyl)baccatin III analogs from taxinine. In: Tetrahedron. 2003 ; Vol. 59, No. 9. pp. 1529-1538.
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