Abstract
2-m-Azidobenzoyl and 2-m-chlorobenzoyl baccatin III analogs were prepared from taxinine, a major component in Japanese yew leaves. In this study, a novel acetyl migration from 13- to 4-hydroxyl group was observed. The antitumor activity of these compounds was evaluated.
Original language | English |
---|---|
Pages (from-to) | 1529-1538 |
Number of pages | 10 |
Journal | Tetrahedron |
Volume | 59 |
Issue number | 9 |
DOIs | |
Publication status | Published - Feb 24 2003 |
Externally published | Yes |
Keywords
- Antitumor activity
- Taxinine
- Taxol
- m-azidobenzoyl
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry