Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.
|Number of pages||4|
|Publication status||Published - Dec 1 2000|
ASJC Scopus subject areas
- Organic Chemistry