Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog

Hitoshi Kondo, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalHeterocyclic Communications
Volume6
Issue number3
Publication statusPublished - Dec 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

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