Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog

Hitoshi Kondo, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journalArticle

10 Citations (Scopus)


Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalHeterocyclic Communications
Issue number3
Publication statusPublished - Dec 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis and antimicrobial activity of unnatural (-)-antimycin A<sub>3</sub> and its analog'. Together they form a unique fingerprint.

  • Cite this