Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog

Hitoshi Kondo, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalHeterocyclic Communications
Volume6
Issue number3
Publication statusPublished - 2000
Externally publishedYes

Fingerprint

Antimycin A
Enantiomers
Alkylation
Chelation
Anti-Bacterial Agents
antimycin

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog. / Kondo, Hitoshi; Oritani, Takayuki; Kiyota, Hiromasa.

In: Heterocyclic Communications, Vol. 6, No. 3, 2000, p. 211-214.

Research output: Contribution to journalArticle

@article{3da5c38273cd4ec39316949dba207d95,
title = "Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog",
abstract = "Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.",
author = "Hitoshi Kondo and Takayuki Oritani and Hiromasa Kiyota",
year = "2000",
language = "English",
volume = "6",
pages = "211--214",
journal = "Heterocyclic Communications",
issn = "0793-0283",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "3",

}

TY - JOUR

T1 - Synthesis and antimicrobial activity of unnatural (-)-antimycin A3 and its analog

AU - Kondo, Hitoshi

AU - Oritani, Takayuki

AU - Kiyota, Hiromasa

PY - 2000

Y1 - 2000

N2 - Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.

AB - Unnatural enantiomer of adilactone antibiotic (-)-antimycin A3 and its deformylamidodehydroxy analog were synthesized using chelation controlled alkylation as a key step. (-)-Antimycin A3 and its analog hardly showed antimicrobial activity compared with natural antimycin A complex. The formal synthesis of natural (+)-antimycin A3 is also achieved.

UR - http://www.scopus.com/inward/record.url?scp=0034379262&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034379262&partnerID=8YFLogxK

M3 - Article

VL - 6

SP - 211

EP - 214

JO - Heterocyclic Communications

JF - Heterocyclic Communications

SN - 0793-0283

IS - 3

ER -