Abstract
The regioisomers (2a,b) of the piperidine ring of febrifugine (1a) and isofebrifugine (1b) were synthesized from 4-allyl-3-piperidone (5). Reduction of 5 afforded a mixture of the trans and cis alcohols (6a,b) without diastereoselectivity; this result differentiated it from the reduction of 2-allyl-3-piperidone (14). The antimalarial di-activity of 2a,b and related compounds was tested.
Original language | English |
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Pages (from-to) | 721-725 |
Number of pages | 5 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 49 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2001 |
Keywords
- Antimalarial activity
- Febrifugine
- Structure-activity relationship
- Synthesis
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery