Synthesis and antimalarial activity of cyclic peroxides, 1,2,4,5,7- pentoxocanes and 1,2,4,5-tetroxanes

Hye Sook Kim, Yasuharu Shibata, Yusuke Wataya, Kaoru Tsuchiya, Araki Masuyama, Masatomo Nojima

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A variety of 1,2,4,5,7-pentoxocane and 1,2,4,5-tetroxane derivatives were prepared as potential peroxide antimalarial agents. In both series of cyclic peroxides, the steric and electronic effects of the substituents attached to the peroxide ring exert a remarkable influence on the antimalarial activity. For some cyclic peroxides, which were found to be highly effective in vitro, the study in vivo has been also conducted.

Original languageEnglish
Pages (from-to)2604-2609
Number of pages6
JournalJournal of medicinal chemistry
Issue number14
Publication statusPublished - Jul 15 1999


ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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