Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives

Kohji Matsumoto; Tominari Choshi; Mai Hourai; Yoshito Zamami; Kenji Sasaki; Takumi Abe; Minoru Ishikura; Noriyuki Hatae; Tatsunori Iwamura; Shigeo Tohyama; Junko Nobuhiro; Satoshi Hibino

doi:10.1016/j.bmcl.2012.05.064

Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives

Kohji Matsumoto, Tominari Choshi, Mai Hourai, Yoshito Zamami, Kenji Sasaki, Takumi Abe, Minoru Ishikura, Noriyuki Hatae, Tatsunori Iwamura, Shigeo Tohyama, Junko Nobuhiro, Satoshi Hibino

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Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4 × 10^-6-1.2 × 10^-7 M.

Original language	English
Pages (from-to)	4762-4764
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	22
Issue number	14
DOIs	https://doi.org/10.1016/j.bmcl.2012.05.064
Publication status	Published - Jul 15 2012

Keywords

Antimalarial activity
Calothrixin A
Calothrixin B
Indolo[3,2-j] phenanthridine
N-Alkyl-calothrixins

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives. / Matsumoto, Kohji; Choshi, Tominari; Hourai, Mai; Zamami, Yoshito; Sasaki, Kenji; Abe, Takumi; Ishikura, Minoru; Hatae, Noriyuki; Iwamura, Tatsunori; Tohyama, Shigeo; Nobuhiro, Junko; Hibino, Satoshi.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 22, No. 14, 15.07.2012, p. 4762-4764.

Research output: Contribution to journal › Article › peer-review

Matsumoto, Kohji ; Choshi, Tominari ; Hourai, Mai ; Zamami, Yoshito ; Sasaki, Kenji ; Abe, Takumi ; Ishikura, Minoru ; Hatae, Noriyuki ; Iwamura, Tatsunori ; Tohyama, Shigeo ; Nobuhiro, Junko ; Hibino, Satoshi. / Synthesis and antimalarial activity of calothrixins A and B, and their N-alkyl derivatives. In: Bioorganic and Medicinal Chemistry Letters. 2012 ; Vol. 22, No. 14. pp. 4762-4764.

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abstract = "We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4 × 10-6-1.2 × 10-7 M.",

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AU - Matsumoto, Kohji

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AU - Zamami, Yoshito

AU - Sasaki, Kenji

AU - Abe, Takumi

AU - Ishikura, Minoru

AU - Hatae, Noriyuki

AU - Iwamura, Tatsunori

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AU - Nobuhiro, Junko

AU - Hibino, Satoshi

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