Abstract
We synthesized calothrixin B using our developed biomimetic method and derived N-alkyl-calothrixins A and B. The in vitro antimalarial activity of the calothrixin derivatives, including calothrixins A and B, against the Plasmodium falciparum FCR-3 strain was evaluated. All test compounds exhibited antimalarial activity over a concentration range of 6.4 × 10-6-1.2 × 10-7 M.
Original language | English |
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Pages (from-to) | 4762-4764 |
Number of pages | 3 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 22 |
Issue number | 14 |
DOIs | |
Publication status | Published - Jul 15 2012 |
Externally published | Yes |
Keywords
- Antimalarial activity
- Calothrixin A
- Calothrixin B
- Indolo[3,2-j] phenanthridine
- N-Alkyl-calothrixins
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry