Synthesis and antifungal activity of the four stereoisomers of streptimidone, a glutarimide antibiotic from Streptomyces rimosus forma paromomycinus

Hitoshi Kondo, Takayuki Oritani, Hiromasa Kiyota

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Four stereoisomers of streptimidone (1), an antibiotic from Streptomyces rimosus forma paromomycinus, were synthesized from methyl (S)-3-hydroxy-2-methylpropanoate. The natural diastereomer 1 shows the strongest antimicrobial activity.

Original languageEnglish
Pages (from-to)3459-3462
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number20
DOIs
Publication statusPublished - Oct 2000
Externally publishedYes

Keywords

  • Aldol reactions
  • Antibiotics
  • Glutarimides
  • Streptimidone
  • Total synthesis

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry

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