Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

Hiromi Nishioka, Koji Uesugi, Norihiro Ueda, Yuka Kondo, Megumi Tsuji, Hitoshi Abe, Takashi Harayama, Takayuki Hamasaki, Masanori Baba, Yasuo Takeuchi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Optically active structural isomers (1b - f and dst-1b - f) of 3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.

Original languageEnglish
Pages (from-to)1075-1076
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume59
Issue number8
DOIs
Publication statusPublished - Aug 2011

Keywords

  • 3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone
  • Anti-human immunodeficiency virus
  • Asymmetric dihydroxylation
  • Coumarin
  • New Mosher's method

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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