Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

Hiromi Nishioka; Koji Uesugi; Norihiro Ueda; Yuka Kondo; Megumi Tsuji; Hitoshi Abe; Takashi Harayama; Takayuki Hamasaki; Masanori Baba; Yasuo Takeuchi

doi:10.1248/cpb.59.1075

Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

Hiromi Nishioka, Koji Uesugi, Norihiro Ueda, Yuka Kondo, Megumi Tsuji, Hitoshi Abe, Takashi Harayama, Takayuki Hamasaki, Masanori Baba, Yasuo Takeuchi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Optically active structural isomers (1b - f and dst-1b - f) of 3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.

Original language	English
Pages (from-to)	1075-1076
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	8
DOIs	https://doi.org/10.1248/cpb.59.1075
Publication status	Published - Aug 2011

Keywords

3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone
Anti-human immunodeficiency virus
Asymmetric dihydroxylation
Coumarin
New Mosher's method

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/cpb.59.1075

Cite this

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abstract = "Optically active structural isomers (1b - f and dst-1b - f) of 3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.",

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year = "2011",

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doi = "10.1248/cpb.59.1075",

language = "English",

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T1 - Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

AU - Nishioka, Hiromi

AU - Uesugi, Koji

AU - Ueda, Norihiro

AU - Kondo, Yuka

AU - Tsuji, Megumi

AU - Abe, Hitoshi

AU - Harayama, Takashi

AU - Hamasaki, Takayuki

AU - Baba, Masanori

AU - Takeuchi, Yasuo

PY - 2011/8

Y1 - 2011/8

N2 - Optically active structural isomers (1b - f and dst-1b - f) of 3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.

AB - Optically active structural isomers (1b - f and dst-1b - f) of 3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.

KW - 3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

KW - Anti-human immunodeficiency virus

KW - Asymmetric dihydroxylation

KW - Coumarin

KW - New Mosher's method

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Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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