Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

Hiromi Nishioka; Koji Uesugi; Norihiro Ueda; Yuka Kondo; Megumi Tsuji; Hitoshi Abe; Takashi Harayama; Takayuki Hamasaki; Masanori Baba; Yasuo Takeuchi

doi:10.1248/cpb.59.1075

Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

Hiromi Nishioka, Koji Uesugi, Norihiro Ueda, Yuka Kondo, Megumi Tsuji, Hitoshi Abe, Takashi Harayama, Takayuki Hamasaki, Masanori Baba, Yasuo Takeuchi

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Optically active structural isomers (1b - f and dst-1b - f) of 3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone (DCK) were synthesized and their anti-human immunodeficiency virus (HIV) activity was investigated. The value of the sensitivity index (SI) of 1b was greater than that of DCK.

Original language	English
Pages (from-to)	1075-1076
Number of pages	2
Journal	Chemical and Pharmaceutical Bulletin
Volume	59
Issue number	8
DOIs	https://doi.org/10.1248/cpb.59.1075
Publication status	Published - Aug 2011

Keywords

3′,4′-di-(O)-(-)-camphanoyl-(+)-khellactone
Anti-human immunodeficiency virus
Asymmetric dihydroxylation
Coumarin
New Mosher's method

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/cpb.59.1075

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Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone. / Nishioka, Hiromi; Uesugi, Koji; Ueda, Norihiro; Kondo, Yuka; Tsuji, Megumi; Abe, Hitoshi; Harayama, Takashi; Hamasaki, Takayuki; Baba, Masanori; Takeuchi, Yasuo.

In: Chemical and Pharmaceutical Bulletin, Vol. 59, No. 8, 08.2011, p. 1075-1076.

Research output: Contribution to journal › Article › peer-review

Nishioka, Hiromi ; Uesugi, Koji ; Ueda, Norihiro ; Kondo, Yuka ; Tsuji, Megumi ; Abe, Hitoshi ; Harayama, Takashi ; Hamasaki, Takayuki ; Baba, Masanori ; Takeuchi, Yasuo. / Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone. In: Chemical and Pharmaceutical Bulletin. 2011 ; Vol. 59, No. 8. pp. 1075-1076.

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AU - Ueda, Norihiro

AU - Kondo, Yuka

AU - Tsuji, Megumi

AU - Abe, Hitoshi

AU - Harayama, Takashi

AU - Hamasaki, Takayuki

AU - Baba, Masanori

AU - Takeuchi, Yasuo

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KW - Asymmetric dihydroxylation

KW - Coumarin

KW - New Mosher's method

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Synthesis and anti-human immunodeficiency virus activity of the skeleton isomers of 3′,,4′-di-(O)-(-)-camphanoyl-(+)-khellactone

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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