Synthesis and anti-angiogenic activity of cortistatin analogs

Yuuki Sato; Hiroshi Kamiyama; Takeo Usui; Tamio Saito; Hiroyuki Osada; Shigefumi Kuwahara; Hiromasa Kiyota

doi:10.1271/bbb.80562

Synthesis and anti-angiogenic activity of cortistatin analogs

Yuuki Sato, Hiroshi Kamiyama, Takeo Usui, Tamio Saito, Hiroyuki Osada, Shigefumi Kuwahara, Hiromasa Kiyota

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

Original language	English
Pages (from-to)	2992-2997
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	72
Issue number	11
DOIs	https://doi.org/10.1271/bbb.80562
Publication status	Published - 2008
Externally published	Yes

Keywords

Angiogenesis
Cortisium simplex
Cortistatin A
HUVEC
Synthesis

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1271/bbb.80562

Cite this

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title = "Synthesis and anti-angiogenic activity of cortistatin analogs",

abstract = "Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.",

keywords = "Angiogenesis, Cortisium simplex, Cortistatin A, HUVEC, Synthesis",

author = "Yuuki Sato and Hiroshi Kamiyama and Takeo Usui and Tamio Saito and Hiroyuki Osada and Shigefumi Kuwahara and Hiromasa Kiyota",

note = "Funding Information: We appreciate the assistance of Mrs Teiko Yamada (Tohoku Univ.) for measuring the NMR and mass spectra, and the useful advice of Dr Takashi Nakahata, Mr Koji Tanaka and Mr Yohsuke Satoh (Tohoku Univ.). Financial support was by grant-aid from Japan Society for the Promotion of Science (no. 19580120).",

year = "2008",

doi = "10.1271/bbb.80562",

language = "English",

volume = "72",

pages = "2992--2997",

journal = "Bioscience, Biotechnology and Biochemistry",

issn = "0916-8451",

publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",

number = "11",

}

TY - JOUR

T1 - Synthesis and anti-angiogenic activity of cortistatin analogs

AU - Sato, Yuuki

AU - Kamiyama, Hiroshi

AU - Usui, Takeo

AU - Saito, Tamio

AU - Osada, Hiroyuki

AU - Kuwahara, Shigefumi

AU - Kiyota, Hiromasa

N1 - Funding Information: We appreciate the assistance of Mrs Teiko Yamada (Tohoku Univ.) for measuring the NMR and mass spectra, and the useful advice of Dr Takashi Nakahata, Mr Koji Tanaka and Mr Yohsuke Satoh (Tohoku Univ.). Financial support was by grant-aid from Japan Society for the Promotion of Science (no. 19580120).

PY - 2008

Y1 - 2008

N2 - Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

AB - Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

KW - Angiogenesis

KW - Cortisium simplex

KW - Cortistatin A

KW - HUVEC

KW - Synthesis

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DO - 10.1271/bbb.80562

M3 - Article

C2 - 18997396

AN - SCOPUS:56749178348

SN - 0916-8451

VL - 72

SP - 2992

EP - 2997

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 11

ER -

Synthesis and anti-angiogenic activity of cortistatin analogs

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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