Synthesis and anti-angiogenic activity of cortistatin analogs

Yuuki Sato, Hiroshi Kamiyama, Takeo Usui, Tamio Saito, Hiroyuki Osada, Shigefumi Kuwahara, Hiromasa Kiyota

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

Original languageEnglish
Pages (from-to)2992-2997
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number11
DOIs
Publication statusPublished - 2008
Externally publishedYes

Fingerprint

Estrone
Porifera
Vascular Endothelial Growth Factor A
cortistatin
isoquinoline

Keywords

  • Angiogenesis
  • Cortisium simplex
  • Cortistatin A
  • HUVEC
  • Synthesis

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Applied Microbiology and Biotechnology
  • Analytical Chemistry
  • Organic Chemistry

Cite this

Sato, Y., Kamiyama, H., Usui, T., Saito, T., Osada, H., Kuwahara, S., & Kiyota, H. (2008). Synthesis and anti-angiogenic activity of cortistatin analogs. Bioscience, Biotechnology and Biochemistry, 72(11), 2992-2997. https://doi.org/10.1271/bbb.80562

Synthesis and anti-angiogenic activity of cortistatin analogs. / Sato, Yuuki; Kamiyama, Hiroshi; Usui, Takeo; Saito, Tamio; Osada, Hiroyuki; Kuwahara, Shigefumi; Kiyota, Hiromasa.

In: Bioscience, Biotechnology and Biochemistry, Vol. 72, No. 11, 2008, p. 2992-2997.

Research output: Contribution to journalArticle

Sato, Y, Kamiyama, H, Usui, T, Saito, T, Osada, H, Kuwahara, S & Kiyota, H 2008, 'Synthesis and anti-angiogenic activity of cortistatin analogs', Bioscience, Biotechnology and Biochemistry, vol. 72, no. 11, pp. 2992-2997. https://doi.org/10.1271/bbb.80562
Sato Y, Kamiyama H, Usui T, Saito T, Osada H, Kuwahara S et al. Synthesis and anti-angiogenic activity of cortistatin analogs. Bioscience, Biotechnology and Biochemistry. 2008;72(11):2992-2997. https://doi.org/10.1271/bbb.80562
Sato, Yuuki ; Kamiyama, Hiroshi ; Usui, Takeo ; Saito, Tamio ; Osada, Hiroyuki ; Kuwahara, Shigefumi ; Kiyota, Hiromasa. / Synthesis and anti-angiogenic activity of cortistatin analogs. In: Bioscience, Biotechnology and Biochemistry. 2008 ; Vol. 72, No. 11. pp. 2992-2997.
@article{18805645cc1047cd85654d506819b162,
title = "Synthesis and anti-angiogenic activity of cortistatin analogs",
abstract = "Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.",
keywords = "Angiogenesis, Cortisium simplex, Cortistatin A, HUVEC, Synthesis",
author = "Yuuki Sato and Hiroshi Kamiyama and Takeo Usui and Tamio Saito and Hiroyuki Osada and Shigefumi Kuwahara and Hiromasa Kiyota",
year = "2008",
doi = "10.1271/bbb.80562",
language = "English",
volume = "72",
pages = "2992--2997",
journal = "Bioscience, Biotechnology and Biochemistry",
issn = "0916-8451",
publisher = "Japan Society for Bioscience Biotechnology and Agrochemistry",
number = "11",

}

TY - JOUR

T1 - Synthesis and anti-angiogenic activity of cortistatin analogs

AU - Sato, Yuuki

AU - Kamiyama, Hiroshi

AU - Usui, Takeo

AU - Saito, Tamio

AU - Osada, Hiroyuki

AU - Kuwahara, Shigefumi

AU - Kiyota, Hiromasa

PY - 2008

Y1 - 2008

N2 - Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

AB - Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

KW - Angiogenesis

KW - Cortisium simplex

KW - Cortistatin A

KW - HUVEC

KW - Synthesis

UR - http://www.scopus.com/inward/record.url?scp=56749178348&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56749178348&partnerID=8YFLogxK

U2 - 10.1271/bbb.80562

DO - 10.1271/bbb.80562

M3 - Article

C2 - 18997396

AN - SCOPUS:56749178348

VL - 72

SP - 2992

EP - 2997

JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

SN - 0916-8451

IS - 11

ER -