Synthesis and anti-angiogenic activity of cortistatin analogs

Yuuki Sato, Hiroshi Kamiyama, Takeo Usui, Tamio Saito, Hiroyuki Osada, Shigefumi Kuwahara, Hiromasa Kiyota

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Analogs of cortistatins, a series of anti-angiogenic compounds isolated from the Indonesian marine sponge Cortisium simplex, were synthesized from estrone by using the Suzuki-Miyaura coupling reaction as the key step. The estrone-isoquinoline hybridized compound showed selective inhibitory activity against the proliferation and VEGF-induced migration of HUVEC.

Original languageEnglish
Pages (from-to)2992-2997
Number of pages6
JournalBioscience, Biotechnology and Biochemistry
Volume72
Issue number11
DOIs
Publication statusPublished - Dec 1 2008
Externally publishedYes

Keywords

  • Angiogenesis
  • Cortisium simplex
  • Cortistatin A
  • HUVEC
  • Synthesis

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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  • Cite this

    Sato, Y., Kamiyama, H., Usui, T., Saito, T., Osada, H., Kuwahara, S., & Kiyota, H. (2008). Synthesis and anti-angiogenic activity of cortistatin analogs. Bioscience, Biotechnology and Biochemistry, 72(11), 2992-2997. https://doi.org/10.1271/bbb.80562