Abstract
N4-Isobutyryl- and -(2-ethylhexanoyl)cytosines (la, b) were synthesized by acylation of cytosine. Y4,2',3',5'-Tetraacylcytidines (III) were synthesized by two methods involving stannic chloride catalysis. One involves condensation of N4-acylcytosines (I) and l-0-acetyl-2,3,5-tri-0-benzoyl-β-D-ribofuranose (II), and the other involves transribosylation between N4-acylcytosines and acyl-inosines or -guanosines (IVa—d). N4-Octanoyl-2',3',5'-triacetylcytidine (Illf) was converted into cytidine by deacylation in a good yield.
Original language | English |
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Pages (from-to) | 3253-3256 |
Number of pages | 4 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 36 |
Issue number | 9 |
DOIs | |
Publication status | Published - 1988 |
Externally published | Yes |
Keywords
- 2',3 ',5 ',-tetraacylcytidine
- N4-acylcytosine N4
- acylinosine
- condensation acylribose
- stannic chloride
- synthesis acylguanosine
- transribosylation
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery