Abstract
Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 2011-2015 |
| Number of pages | 5 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 45 |
| Issue number | 12 |
| Publication status | Published - 1997 |
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Keywords
- 3(2H)-benzofuranone
- Antifungal activity
- Griseofulvin
- Thiogriseofulvin
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry
- Chemistry(all)
- Pharmacology
Cite this
Syntheses and antifungal activity of dl-griseofulvin and its congeners. III. / Takeuchi, Yasuo; Watanabe, Ikuo; Misumi, Keiji; Irie, Mari; Hirose, Yoko; Hirata, Kazumi; Yamato, Masatoshi; Harayama, Takashi.
In: Chemical and Pharmaceutical Bulletin, Vol. 45, No. 12, 1997, p. 2011-2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Syntheses and antifungal activity of dl-griseofulvin and its congeners. III
AU - Takeuchi, Yasuo
AU - Watanabe, Ikuo
AU - Misumi, Keiji
AU - Irie, Mari
AU - Hirose, Yoko
AU - Hirata, Kazumi
AU - Yamato, Masatoshi
AU - Harayama, Takashi
PY - 1997
Y1 - 1997
N2 - Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.
AB - Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.
KW - 3(2H)-benzofuranone
KW - Antifungal activity
KW - Griseofulvin
KW - Thiogriseofulvin
UR - http://www.scopus.com/inward/record.url?scp=0031472272&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031472272&partnerID=8YFLogxK
M3 - Article
C2 - 9433771
AN - SCOPUS:0031472272
VL - 45
SP - 2011
EP - 2015
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
SN - 0009-2363
IS - 12
ER -