Syntheses and antifungal activity of dl-griseofulvin and its congeners. III

Yasuo Takeuchi, Ikuo Watanabe, Keiji Misumi, Mari Irie, Yoko Hirose, Kazumi Hirata, Masatoshi Yamato, Takashi Harayama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.

Original languageEnglish
Pages (from-to)2011-2015
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number12
Publication statusPublished - 1997

Fingerprint

Griseofulvin
Benzene

Keywords

  • 3(2H)-benzofuranone
  • Antifungal activity
  • Griseofulvin
  • Thiogriseofulvin

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Takeuchi, Y., Watanabe, I., Misumi, K., Irie, M., Hirose, Y., Hirata, K., ... Harayama, T. (1997). Syntheses and antifungal activity of dl-griseofulvin and its congeners. III. Chemical and Pharmaceutical Bulletin, 45(12), 2011-2015.

Syntheses and antifungal activity of dl-griseofulvin and its congeners. III. / Takeuchi, Yasuo; Watanabe, Ikuo; Misumi, Keiji; Irie, Mari; Hirose, Yoko; Hirata, Kazumi; Yamato, Masatoshi; Harayama, Takashi.

In: Chemical and Pharmaceutical Bulletin, Vol. 45, No. 12, 1997, p. 2011-2015.

Research output: Contribution to journalArticle

Takeuchi, Y, Watanabe, I, Misumi, K, Irie, M, Hirose, Y, Hirata, K, Yamato, M & Harayama, T 1997, 'Syntheses and antifungal activity of dl-griseofulvin and its congeners. III', Chemical and Pharmaceutical Bulletin, vol. 45, no. 12, pp. 2011-2015.
Takeuchi Y, Watanabe I, Misumi K, Irie M, Hirose Y, Hirata K et al. Syntheses and antifungal activity of dl-griseofulvin and its congeners. III. Chemical and Pharmaceutical Bulletin. 1997;45(12):2011-2015.
Takeuchi, Yasuo ; Watanabe, Ikuo ; Misumi, Keiji ; Irie, Mari ; Hirose, Yoko ; Hirata, Kazumi ; Yamato, Masatoshi ; Harayama, Takashi. / Syntheses and antifungal activity of dl-griseofulvin and its congeners. III. In: Chemical and Pharmaceutical Bulletin. 1997 ; Vol. 45, No. 12. pp. 2011-2015.
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