Syntheses and antifungal activity of dl-griseofulvin and its congeners. III

Yasuo Takeuchi, Ikuo Watanabe, Keiji Misumi, Mari Irie, Yoko Hirose, Kazumi Hirata, Masatoshi Yamato, Takashi Harayama

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Abstract

Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.

Original languageEnglish
Pages (from-to)2011-2015
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume45
Issue number12
Publication statusPublished - 1997

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Keywords

  • 3(2H)-benzofuranone
  • Antifungal activity
  • Griseofulvin
  • Thiogriseofulvin

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Takeuchi, Y., Watanabe, I., Misumi, K., Irie, M., Hirose, Y., Hirata, K., Yamato, M., & Harayama, T. (1997). Syntheses and antifungal activity of dl-griseofulvin and its congeners. III. Chemical and Pharmaceutical Bulletin, 45(12), 2011-2015.