Syntheses and antifungal activity of dl-griseofulvin and its congeners. III

Yasuo Takeuchi; Ikuo Watanabe; Keiji Misumi; Mari Irie; Yoko Hirose; Kazumi Hirata; Masatoshi Yamato; Takashi Harayama

doi:10.1248/cpb.45.2011

Syntheses and antifungal activity of dl-griseofulvin and its congeners. III

Yasuo Takeuchi, Ikuo Watanabe, Keiji Misumi, Mari Irie, Yoko Hirose, Kazumi Hirata, Masatoshi Yamato, Takashi Harayama

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.

Original language	English
Pages (from-to)	2011-2015
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	45
Issue number	12
DOIs	https://doi.org/10.1248/cpb.45.2011
Publication status	Published - 1997

Keywords

3(2H)-benzofuranone
Antifungal activity
Griseofulvin
Thiogriseofulvin

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.45.2011

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AU - Takeuchi, Yasuo

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AU - Misumi, Keiji

AU - Irie, Mari

AU - Hirose, Yoko

AU - Hirata, Kazumi

AU - Yamato, Masatoshi

AU - Harayama, Takashi

PY - 1997

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AB - Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.

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KW - Antifungal activity

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KW - Thiogriseofulvin

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Syntheses and antifungal activity of dl-griseofulvin and its congeners. III

Abstract

Keywords

ASJC Scopus subject areas

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