Abstract
Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.
Original language | English |
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Pages (from-to) | 2011-2015 |
Number of pages | 5 |
Journal | Chemical and Pharmaceutical Bulletin |
Volume | 45 |
Issue number | 12 |
DOIs | |
Publication status | Published - 1997 |
Keywords
- 3(2H)-benzofuranone
- Antifungal activity
- Griseofulvin
- Thiogriseofulvin
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery