Abstract
Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 2011-2015 |
| Number of pages | 5 |
| Journal | Chemical and Pharmaceutical Bulletin |
| Volume | 45 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - Jan 1 1997 |
Keywords
- 3(2H)-benzofuranone
- Antifungal activity
- Griseofulvin
- Thiogriseofulvin
ASJC Scopus subject areas
- Chemistry(all)
- Drug Discovery
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Takeuchi, Y., Watanabe, I., Misumi, K., Irie, M., Hirose, Y., Hirata, K., Yamato, M., & Harayama, T. (1997). Syntheses and antifungal activity of dl-griseofulvin and its congeners. III. Chemical and Pharmaceutical Bulletin, 45(12), 2011-2015. https://doi.org/10.1248/cpb.45.2011