Several congeners (1b-g), with novel substituents on the benzene ring of griseofulvin, were prepared by the application of a synthetic method developed by us. Antifungal activity of these congeners decreased in order of dl-griseofulvin (1a)=1d > 1b, c >> 1e-f (inactive). The relationship between the antifungal activity and the position or kind of substituents on the benzene ring of griseofulvin is discussed.
|Number of pages||5|
|Journal||Chemical and Pharmaceutical Bulletin|
|Publication status||Published - 1997|
- Antifungal activity
ASJC Scopus subject areas
- Drug Discovery
- Organic Chemistry