Syntheses and Antifungal Activities of dl-Griseofulvin and Its Congeners: I

Hideo Tomozane, Yasuo Takeuchi, Tominari Choshi, Shoko Kishida, Masatoshi Yamato

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19 Citations (Scopus)

Abstract

dl-Griseofulvin (la) was prepared by two synthetic pathways. New 6'-congeners (3 and 4) of griseofulvin were also prepared. Their antifungal activities were evaluated and compounds 3 and 4 were found to be less active than la. Molecular calculations on la, dl-epigriseofulvin (lb), 3 and 4 were undertaken.

Original languageEnglish
Pages (from-to)925-929
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume38
Issue number4
DOIs
Publication statusPublished - Jan 1 1990

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Keywords

  • Diels-Alder reaction
  • antifungal activity
  • dl-griseofulvin
  • molecular calculation

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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