Syntheses and Anti-Inflammatory and Analgesic Activities of Hydroxamic Acids and Acid Hydrazides

On the basis of the generally accepted view that copper ions take part in the occurrence of inflammation, hydroxamic acids and acid hydrazides derived from various substituted cinnamic acids and hydrocinnamic acids, which were expected to chelate with copper ions, were synthesized and evaluated for anti-inflammatory activity by the carrageenin-induced rat paw edema assay and for analgesic activity by the phenylquinone writhing method in mice. Some of the synthesized compounds exhibited both activities, and 3-(3,4-dimethoxyphenyl)propiohydroxamic acid and its Zn complex were more active than aspirin. The Cu(II) complexes of hydroxamic acid derivatives were synthesized and were assumed to have polymeric structures from the results of elemental analysis, molecular weight measurement and determination of magnetic susceptibility. hydroxamic acid acid hydrazide cinnamic acid hydrocinnamic acid Cu(II) complex Zn(II) complex cluster anti-inflammatory activity analgesic activity.