Syntaxin 1 (HPC-1) is associated with chromaffin granules

M. Tagaya, S. Toyonaga, M. Takahashi, A. Yamamoto, T. Fujiwara, K. Akagawa, Y. Moriyama, S. Mizushima

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Abstract

Syntaxin 1 (HPC-1), a component of the receptor for SNAPs (soluble N- ethylmaleimide-sensitive factor attachment proteins), has been implicated in the docking and fusion of synaptic vesicles with the plasma membrane. It was reported that syntaxin 1 in rat brain and chromaffin cells (PC12) is exclusively located on the plasma membrane (Bennett, M. K., Calakos, N., and Scheller, R. H. (1992) Science 257, 255-259; Sollner, T., Bennett, M. K., Whiteheart, S. W., Scheller, R. H., and Rothman, J. E. (1993) Cell 75, 409- 418). By means of biochemical and morphological analyses, we now show that syntaxin 1 is associated with chromaffin granules in the adrenal medulla. This finding raises the possibility that syntaxin 1 in chromaffin cells is a component of vesicle-SNAP receptor as well as one of target-SNAP receptor on the plasma membrane.

Original languageEnglish
Pages (from-to)15930-15933
Number of pages4
JournalJournal of Biological Chemistry
Volume270
Issue number27
DOIs
Publication statusPublished - 1995
Externally publishedYes

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Syntaxin 1
Chromaffin Granules
SNARE Proteins
Cell membranes
Chromaffin Cells
Cell Membrane
Adrenal Medulla
Synaptic Vesicles
Rats
Brain
Fusion reactions

ASJC Scopus subject areas

  • Biochemistry

Cite this

Tagaya, M., Toyonaga, S., Takahashi, M., Yamamoto, A., Fujiwara, T., Akagawa, K., ... Mizushima, S. (1995). Syntaxin 1 (HPC-1) is associated with chromaffin granules. Journal of Biological Chemistry, 270(27), 15930-15933. https://doi.org/10.1074/jbc.270.27.15930

Syntaxin 1 (HPC-1) is associated with chromaffin granules. / Tagaya, M.; Toyonaga, S.; Takahashi, M.; Yamamoto, A.; Fujiwara, T.; Akagawa, K.; Moriyama, Y.; Mizushima, S.

In: Journal of Biological Chemistry, Vol. 270, No. 27, 1995, p. 15930-15933.

Research output: Contribution to journalArticle

Tagaya, M, Toyonaga, S, Takahashi, M, Yamamoto, A, Fujiwara, T, Akagawa, K, Moriyama, Y & Mizushima, S 1995, 'Syntaxin 1 (HPC-1) is associated with chromaffin granules', Journal of Biological Chemistry, vol. 270, no. 27, pp. 15930-15933. https://doi.org/10.1074/jbc.270.27.15930
Tagaya M, Toyonaga S, Takahashi M, Yamamoto A, Fujiwara T, Akagawa K et al. Syntaxin 1 (HPC-1) is associated with chromaffin granules. Journal of Biological Chemistry. 1995;270(27):15930-15933. https://doi.org/10.1074/jbc.270.27.15930
Tagaya, M. ; Toyonaga, S. ; Takahashi, M. ; Yamamoto, A. ; Fujiwara, T. ; Akagawa, K. ; Moriyama, Y. ; Mizushima, S. / Syntaxin 1 (HPC-1) is associated with chromaffin granules. In: Journal of Biological Chemistry. 1995 ; Vol. 270, No. 27. pp. 15930-15933.
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