Synergistic antitumor effects of tumor necrosis factor ALPHA. and interleukin 2 mini-pellet

Tadashi Onoda, Kenichi Sakagami, Junji Matsuoka, Shigehiro Shiozaki, Susumu Uchida, Toshiyoshi Fujiwara, Kun Zou Orita, Keiji Fujioka, Yyshihiro Takada

Research output: Contribution to journalArticle

Abstract

Synergistic antitumor effects of tumor necrosis factor α and interleukin 2 mini-pellet We have investigated the antitomor effect of IL 2 mini pellet on the therapy of murine Meth-A sarcoma in these years. In this study we used IL-2 mini-pellet with a small dose of nHuTNF-α and examined of its antitumor efficacy compared with the administration of IL-2 mini-pellet alone. Even a single administration of IL-2 mini pellet alone could inhibited the growth of Meth-A sarcoma that had transplanted in mice, the combined use was more effective. The lytic activity of splenocytes against YAC-1 cells was prolonged in the combined use, but the maximum level of that was same. In histological examination on day 7 afterthe administration, the infiltration of lymphocytes was found in a same extent.

Original languageEnglish
Pages (from-to)381-385
Number of pages5
JournalDrug Delivery System
Volume6
Issue number5
DOIs
Publication statusPublished - 1991

Keywords

  • combination immunotheropy
  • interleukin–2
  • tumor necrosis factor slow delivery

ASJC Scopus subject areas

  • Pharmaceutical Science

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    Onoda, T., Sakagami, K., Matsuoka, J., Shiozaki, S., Uchida, S., Fujiwara, T., Orita, K. Z., Fujioka, K., & Takada, Y. (1991). Synergistic antitumor effects of tumor necrosis factor ALPHA. and interleukin 2 mini-pellet. Drug Delivery System, 6(5), 381-385. https://doi.org/10.2745/dds.6.381