Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats

Teruko Takano-Yamamoto, Kiyo Sasaki, Goudarzi Fatemeh, Tomohiro Fukunaga, Masahiro Seiryu, Takayoshi Daimaruya, Nobuo Takeshita, Hiroshi Kamioka, Taiji Adachi, Hiroto Ida, Atsushi Mayama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Several recent prospective clinical trials have investigated the effect of supplementary vibration applied with fixed appliances in an attempt to accelerate tooth movement and shorten the duration of orthodontic treatment. Among them, some studies reported an increase in the rate of tooth movement, but others did not. This technique is still controversial, and the underlying cellular and molecular mechanisms remain unclear. In the present study, we developed a new vibration device for a tooth movement model in rats, and investigated the efficacy and safety of the device when used with fixed appliances. The most effective level of supplementary vibration to accelerate tooth movement stimulated by a continuous static force was 3 gf at 70 Hz for 3 minutes once a week. Furthermore, at this optimum-magnitude, high-frequency vibration could synergistically enhance osteoclastogenesis and osteoclast function via NF-κB activation, leading to alveolar bone resorption and finally, accelerated tooth movement, but only when a static force was continuously applied to the teeth. These findings contribute to a better understanding of the mechanism by which optimum-magnitude high-frequency vibration accelerates tooth movement, and may lead to novel approaches for the safe and effective treatment of malocclusion.

Original languageEnglish
Article number13969
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 1 2017

Fingerprint

Tooth Movement Techniques
Vibration
Protective Devices
Alveolar Bone Loss
Malocclusion
Osteoclasts
Bone Resorption
Orthodontics
Osteogenesis
Tooth
Clinical Trials
Equipment and Supplies

ASJC Scopus subject areas

  • General

Cite this

Takano-Yamamoto, T., Sasaki, K., Fatemeh, G., Fukunaga, T., Seiryu, M., Daimaruya, T., ... Mayama, A. (2017). Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats. Scientific Reports, 7(1), [13969]. https://doi.org/10.1038/s41598-017-13541-7

Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats. / Takano-Yamamoto, Teruko; Sasaki, Kiyo; Fatemeh, Goudarzi; Fukunaga, Tomohiro; Seiryu, Masahiro; Daimaruya, Takayoshi; Takeshita, Nobuo; Kamioka, Hiroshi; Adachi, Taiji; Ida, Hiroto; Mayama, Atsushi.

In: Scientific Reports, Vol. 7, No. 1, 13969, 01.12.2017.

Research output: Contribution to journalArticle

Takano-Yamamoto, T, Sasaki, K, Fatemeh, G, Fukunaga, T, Seiryu, M, Daimaruya, T, Takeshita, N, Kamioka, H, Adachi, T, Ida, H & Mayama, A 2017, 'Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats', Scientific Reports, vol. 7, no. 1, 13969. https://doi.org/10.1038/s41598-017-13541-7
Takano-Yamamoto, Teruko ; Sasaki, Kiyo ; Fatemeh, Goudarzi ; Fukunaga, Tomohiro ; Seiryu, Masahiro ; Daimaruya, Takayoshi ; Takeshita, Nobuo ; Kamioka, Hiroshi ; Adachi, Taiji ; Ida, Hiroto ; Mayama, Atsushi. / Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
@article{c132d76b897744c8b6d00b98ec735798,
title = "Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats",
abstract = "Several recent prospective clinical trials have investigated the effect of supplementary vibration applied with fixed appliances in an attempt to accelerate tooth movement and shorten the duration of orthodontic treatment. Among them, some studies reported an increase in the rate of tooth movement, but others did not. This technique is still controversial, and the underlying cellular and molecular mechanisms remain unclear. In the present study, we developed a new vibration device for a tooth movement model in rats, and investigated the efficacy and safety of the device when used with fixed appliances. The most effective level of supplementary vibration to accelerate tooth movement stimulated by a continuous static force was 3 gf at 70 Hz for 3 minutes once a week. Furthermore, at this optimum-magnitude, high-frequency vibration could synergistically enhance osteoclastogenesis and osteoclast function via NF-κB activation, leading to alveolar bone resorption and finally, accelerated tooth movement, but only when a static force was continuously applied to the teeth. These findings contribute to a better understanding of the mechanism by which optimum-magnitude high-frequency vibration accelerates tooth movement, and may lead to novel approaches for the safe and effective treatment of malocclusion.",
author = "Teruko Takano-Yamamoto and Kiyo Sasaki and Goudarzi Fatemeh and Tomohiro Fukunaga and Masahiro Seiryu and Takayoshi Daimaruya and Nobuo Takeshita and Hiroshi Kamioka and Taiji Adachi and Hiroto Ida and Atsushi Mayama",
year = "2017",
month = "12",
day = "1",
doi = "10.1038/s41598-017-13541-7",
language = "English",
volume = "7",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Synergistic acceleration of experimental tooth movement by supplementary high-frequency vibration applied with a static force in rats

AU - Takano-Yamamoto, Teruko

AU - Sasaki, Kiyo

AU - Fatemeh, Goudarzi

AU - Fukunaga, Tomohiro

AU - Seiryu, Masahiro

AU - Daimaruya, Takayoshi

AU - Takeshita, Nobuo

AU - Kamioka, Hiroshi

AU - Adachi, Taiji

AU - Ida, Hiroto

AU - Mayama, Atsushi

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Several recent prospective clinical trials have investigated the effect of supplementary vibration applied with fixed appliances in an attempt to accelerate tooth movement and shorten the duration of orthodontic treatment. Among them, some studies reported an increase in the rate of tooth movement, but others did not. This technique is still controversial, and the underlying cellular and molecular mechanisms remain unclear. In the present study, we developed a new vibration device for a tooth movement model in rats, and investigated the efficacy and safety of the device when used with fixed appliances. The most effective level of supplementary vibration to accelerate tooth movement stimulated by a continuous static force was 3 gf at 70 Hz for 3 minutes once a week. Furthermore, at this optimum-magnitude, high-frequency vibration could synergistically enhance osteoclastogenesis and osteoclast function via NF-κB activation, leading to alveolar bone resorption and finally, accelerated tooth movement, but only when a static force was continuously applied to the teeth. These findings contribute to a better understanding of the mechanism by which optimum-magnitude high-frequency vibration accelerates tooth movement, and may lead to novel approaches for the safe and effective treatment of malocclusion.

AB - Several recent prospective clinical trials have investigated the effect of supplementary vibration applied with fixed appliances in an attempt to accelerate tooth movement and shorten the duration of orthodontic treatment. Among them, some studies reported an increase in the rate of tooth movement, but others did not. This technique is still controversial, and the underlying cellular and molecular mechanisms remain unclear. In the present study, we developed a new vibration device for a tooth movement model in rats, and investigated the efficacy and safety of the device when used with fixed appliances. The most effective level of supplementary vibration to accelerate tooth movement stimulated by a continuous static force was 3 gf at 70 Hz for 3 minutes once a week. Furthermore, at this optimum-magnitude, high-frequency vibration could synergistically enhance osteoclastogenesis and osteoclast function via NF-κB activation, leading to alveolar bone resorption and finally, accelerated tooth movement, but only when a static force was continuously applied to the teeth. These findings contribute to a better understanding of the mechanism by which optimum-magnitude high-frequency vibration accelerates tooth movement, and may lead to novel approaches for the safe and effective treatment of malocclusion.

UR - http://www.scopus.com/inward/record.url?scp=85032303783&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85032303783&partnerID=8YFLogxK

U2 - 10.1038/s41598-017-13541-7

DO - 10.1038/s41598-017-13541-7

M3 - Article

C2 - 29070874

AN - SCOPUS:85032303783

VL - 7

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 13969

ER -