Syndrome of inappropriate antidiuretic hormone secretion following liver transplantation

Kosei Takagi, Takahito Yagi, Susumu Shinoura, Yuzo Umeda, Ryuichi Yoshida, Daisuke Nobuoka, Nobuyuki Watanabe, Takashi Kuise, Tomokazu Fuji, Hiroyuki Araki, Toshiyoshi Fujiwara

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1 Citation (Scopus)

Abstract

Syndrome of inappropriate antidiuretic hormone secretion (SIADH) is an extremely rare cause of hyponatremia post-liver transplantation. A 15-year-old Japanese girl with recurrent cholangitis after Kasai surgery for biliary atresia underwent successful living donor liver transplantation. Peritonitis due to gastrointestinal perforation occurred. Hyponatremia gradually developed but improved after hypertonic sodium treatment. One month later, severe hyponatremia rapidly recurred. We considered the hyponatremia's cause as SIADH. We suspected that tacrolimus was the disease's cause, so we used cyclosporine instead, plus hypertonic sodium plus water intake restriction, which improved the hyponatremia. Symptomatic hyponatremia manifested by SIADH is a rare, serious complication post-liver transplantation.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
JournalActa medica Okayama
Volume71
Issue number1
Publication statusPublished - 2017

Keywords

  • Hyponatremia
  • Liver transplantation
  • SIADH
  • Syndrome of inappropriate antidiuretic hormone secretion
  • Tacrolimus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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