Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans

Satoshi Iwase, Tadaaki Mano, Atsunori Kamiya, Yuki Niimi, Qi Fu, Akio Suzumura

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This study aimed at examining whether the properties of microneurographically recorded muscle sympathetic nerve activity (MSNA) were altered during hypotensive attacks. A retrospective study was performed on 74 subjects who participated in tilt studies when vasodepressive syncope was induced incidentally in six subjects. The specific features of MSNA that distinguish this activity from skin sympathetic nerve activity are (1) rhythmic pulse synchronous burst discharge, (2) a duration of approximately 150-300 ms, and (3) no response to arousal stimuli were abolished during the syncopal attack. The altered features observed during the syncopal attack in these six subjects were (1) scattered reflex latencies of MSNA peak from the ECG R-wave, (2) elongated burst duration twice to five times as long as that in conscious state, and (3) response to arousal stimuli. The reduced input from the baroreceptors due to suppression on the central sympathetic volley proximal to the nucleus tractus solitarius might be attributed to the lost features characteristic of MSNA.

Original languageEnglish
Pages (from-to)141-145
Number of pages5
JournalAutonomic Neuroscience: Basic and Clinical
Volume95
Issue number1-2
DOIs
Publication statusPublished - Jan 10 2002
Externally publishedYes

Fingerprint

Human Activities
Muscles
Arousal
Pressoreceptors
Solitary Nucleus
Syncope
Reflex
Pulse
Electrocardiography
Retrospective Studies
Skin

Keywords

  • Baroreflex
  • Microneurography
  • Muscle sympathetic nerve activity
  • Vasovagal syncope

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans. / Iwase, Satoshi; Mano, Tadaaki; Kamiya, Atsunori; Niimi, Yuki; Fu, Qi; Suzumura, Akio.

In: Autonomic Neuroscience: Basic and Clinical, Vol. 95, No. 1-2, 10.01.2002, p. 141-145.

Research output: Contribution to journalArticle

Iwase, Satoshi ; Mano, Tadaaki ; Kamiya, Atsunori ; Niimi, Yuki ; Fu, Qi ; Suzumura, Akio. / Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans. In: Autonomic Neuroscience: Basic and Clinical. 2002 ; Vol. 95, No. 1-2. pp. 141-145.
@article{e7834c29ac7d4fa3a20dd4a071deee4c,
title = "Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans",
abstract = "This study aimed at examining whether the properties of microneurographically recorded muscle sympathetic nerve activity (MSNA) were altered during hypotensive attacks. A retrospective study was performed on 74 subjects who participated in tilt studies when vasodepressive syncope was induced incidentally in six subjects. The specific features of MSNA that distinguish this activity from skin sympathetic nerve activity are (1) rhythmic pulse synchronous burst discharge, (2) a duration of approximately 150-300 ms, and (3) no response to arousal stimuli were abolished during the syncopal attack. The altered features observed during the syncopal attack in these six subjects were (1) scattered reflex latencies of MSNA peak from the ECG R-wave, (2) elongated burst duration twice to five times as long as that in conscious state, and (3) response to arousal stimuli. The reduced input from the baroreceptors due to suppression on the central sympathetic volley proximal to the nucleus tractus solitarius might be attributed to the lost features characteristic of MSNA.",
keywords = "Baroreflex, Microneurography, Muscle sympathetic nerve activity, Vasovagal syncope",
author = "Satoshi Iwase and Tadaaki Mano and Atsunori Kamiya and Yuki Niimi and Qi Fu and Akio Suzumura",
year = "2002",
month = "1",
day = "10",
doi = "10.1016/S1566-0702(01)00362-9",
language = "English",
volume = "95",
pages = "141--145",
journal = "Autonomic Neuroscience: Basic and Clinical",
issn = "1566-0702",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - Syncopal attack alters the burst properties of muscle sympathetic nerve activity in humans

AU - Iwase, Satoshi

AU - Mano, Tadaaki

AU - Kamiya, Atsunori

AU - Niimi, Yuki

AU - Fu, Qi

AU - Suzumura, Akio

PY - 2002/1/10

Y1 - 2002/1/10

N2 - This study aimed at examining whether the properties of microneurographically recorded muscle sympathetic nerve activity (MSNA) were altered during hypotensive attacks. A retrospective study was performed on 74 subjects who participated in tilt studies when vasodepressive syncope was induced incidentally in six subjects. The specific features of MSNA that distinguish this activity from skin sympathetic nerve activity are (1) rhythmic pulse synchronous burst discharge, (2) a duration of approximately 150-300 ms, and (3) no response to arousal stimuli were abolished during the syncopal attack. The altered features observed during the syncopal attack in these six subjects were (1) scattered reflex latencies of MSNA peak from the ECG R-wave, (2) elongated burst duration twice to five times as long as that in conscious state, and (3) response to arousal stimuli. The reduced input from the baroreceptors due to suppression on the central sympathetic volley proximal to the nucleus tractus solitarius might be attributed to the lost features characteristic of MSNA.

AB - This study aimed at examining whether the properties of microneurographically recorded muscle sympathetic nerve activity (MSNA) were altered during hypotensive attacks. A retrospective study was performed on 74 subjects who participated in tilt studies when vasodepressive syncope was induced incidentally in six subjects. The specific features of MSNA that distinguish this activity from skin sympathetic nerve activity are (1) rhythmic pulse synchronous burst discharge, (2) a duration of approximately 150-300 ms, and (3) no response to arousal stimuli were abolished during the syncopal attack. The altered features observed during the syncopal attack in these six subjects were (1) scattered reflex latencies of MSNA peak from the ECG R-wave, (2) elongated burst duration twice to five times as long as that in conscious state, and (3) response to arousal stimuli. The reduced input from the baroreceptors due to suppression on the central sympathetic volley proximal to the nucleus tractus solitarius might be attributed to the lost features characteristic of MSNA.

KW - Baroreflex

KW - Microneurography

KW - Muscle sympathetic nerve activity

KW - Vasovagal syncope

UR - http://www.scopus.com/inward/record.url?scp=0037050313&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037050313&partnerID=8YFLogxK

U2 - 10.1016/S1566-0702(01)00362-9

DO - 10.1016/S1566-0702(01)00362-9

M3 - Article

C2 - 11871780

AN - SCOPUS:0037050313

VL - 95

SP - 141

EP - 145

JO - Autonomic Neuroscience: Basic and Clinical

JF - Autonomic Neuroscience: Basic and Clinical

SN - 1566-0702

IS - 1-2

ER -