Synaptic Multivesicular Release in the Cerebellar Cortex: Its Mechanism and Role in Neural Encoding and Processing

Shin’Ichiro I. Satake, Tsuyoshi Inoue, Keiji Imoto

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The number of synaptic vesicles released during fast release plays a major role in determining the strength of postsynaptic response. However, it remains unresolved how the number of vesicles released in response to action potentials is controlled at a single synapse. Recent findings suggest that the Cav2.1 subtype (P/Q-type) of voltage-gated calcium channels is responsible for inducing presynaptic multivesicular release (MVR) at rat cerebellar glutamatergic synapses from granule cells to molecular layer interneurons. The topographical distance from Cav2.1 channels to exocytotic Ca2+ sensors is a critical determinant of MVR. In physiological trains of presynaptic neurons, MVR significantly impacts the excitability of postsynaptic neurons, not only by increasing peak amplitude but also by prolonging decay time of the postsynaptic currents. Therefore, MVR contributes additional complexity to neural encoding and processing in the cerebellar cortex.

Original languageEnglish
Pages (from-to)201-207
Number of pages7
JournalCerebellum
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1 2016

Keywords

  • Ca microdomain
  • Ca2 channel subtype
  • Excitatory postsynaptic current
  • Granule cell
  • Kinetics
  • Molecular layer interneuron
  • Paired-pulse ratio

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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